AI Article Synopsis
- Immunoglobulin-like transcript 3 (ILT3) is identified as an inhibitory receptor that may induce T cell anergy, which has implications in disorders like transplantation, autoimmunity, and allergies.
- In colorectal cancer, high ILT3 expression was found in 64.7% of tumor specimens, significantly more than in adjacent normal tissues, and was associated with advanced disease and poor overall survival (OS).
- High ILT3 expression negatively correlates with CD45RO+ T cell density, suggesting its potential role in tumor progression through the modulation of T cell activity in the tumor microenvironment.
Article Abstract
Immunoglobulin like transcript 3 (ILT3) was previously identified as an inhibitory receptor to induce T cell anergy in tranplantation, autoimmunity and allergy. Here we aimed to investigate the expression of ILT3 in colorectal cancer, analyze the association between ILT3 expression and clinicopathological variables and prognosis, and evaluate the correlation between the expression of ILT3 and CD45RO+ T cells density. Expression of ILT3 was identified on the cell membrane and/or in the cytoplasm. High expression ILT3 was identified in 55 of 85 (64.7%) tumor specimens, which was significantly higher than that in the adjacent normal tissues(5/30) (P < 0.001). High ILT3 expression was significantly associated with positive lymph node metastasis (N1-2; P = 0.03), advanced disease (stage III-IV; P = 0.03), and reduced OS in patients. The ILT3 expression level was an independent prognostic factor (P = 0.004) and inversely correlated with the number of CD45RO+ T cells (P = 0.019). In the present study, high ILT3 expression was observed in colorectal cancer and inversely associated with CD45RO+ T cells density and prognosis, suggesting that ILT3 played an important role in tumor progression by possible influence on CD45RO+ T cells in the tumor microenvironment.
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| http://dx.doi.org/10.1016/j.prp.2018.07.026 | DOI Listing |
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