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Impact of psychological stress on ovarian function: Insights, mechanisms and intervention strategies (Review).
Int J Mol Med
February 2025
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.
Mental stress may lead to ovarian dysfunction. Psychological stress disrupts ovarian function, leading to adverse fertilization outcomes, premature ovarian insufficiency and decreased ovarian reserve. Furthermore, psychological stress caused by decreased ovarian function and infertility can exacerbate the mental burden.
View Article and Find Full Text PDFThe relationship between psychological stress and ovulatory disorders and its molecular mechanisms: a narrative review.
J Psychosom Obstet Gynaecol
December 2024
Assisted Reproduction Unit, Department of Gynecology and Obstetrics, Sir Run Run Shaw Hospital, Hangzhou, China.
This narrative review explores the relationship between psychological stress and ovulatory disorders, focusing on the molecular mechanisms involved. Ovulation is regulated by the hypothalamus-pituitary-ovarian (HPO) axis, and disruptions in this axis can lead to ovulatory dysfunction. Chronic psychological stress affects the HPO axis, resulting in abnormalities in hypothalamus hormone secretion, pituitary hormone release, and ovarian function.
View Article and Find Full Text PDFWhen is the use of intravenous immunoglobulin appropriate in immune thrombocytopenia?
Br J Haematol
December 2024
Internal Medicine Department, Centre National de Référence des Cytopénies Auto-Immunes de l'Adulte, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris-Est Créteil (UPEC), Créteil, France.
Article Synopsis
- Intravenous immunoglobulin (IVIg) is a preferred treatment for severe immune thrombocytopaenia (ITP), but its high cost and limited availability led to specific French guidelines on its use.
- A study assessed IVIg prescribing practices in real-life situations, evaluating compliance with these French guidelines in a sample of 114 hospitalized patients from 2016 to 2020.
- Findings showed that 84.4% of IVIg prescriptions were compliant with guidelines, and the use was notably more frequent among younger patients, with factors like corticosteroid resistance and need for surgical preparation influencing non-compliance.
Initial treatment efficacy and safety of durvalumab plus tremelimumab combination therapy in unresectable hepatocellular carcinoma in clinical practice.
JGH Open
October 2024
Department of Gastroenterology and Oncology, Institute of Biomedical Sciences Tokushima University Graduate School of Medicine Tokushima Japan.
Article Synopsis
- This study evaluated the effectiveness and safety of durvalumab plus tremelimumab (Dur + Tre) for patients with unresectable hepatocellular carcinoma (uHCC) using a retrospective analysis of 37 patients from 2023 to 2024.
- The first-line group showed a disease control rate of 80.9%, significantly surpassing the later-line group's 50%, while immune-related adverse events were reported in 24.3% of patients, mostly mild to moderate.
- Overall, first-line Dur + Tre therapy proved more beneficial, with a high transition rate of 94.7% to second-line treatment following disease progression, indicating its potential as a preferred initial treatment option.
Failure Rates of Conservative Management of Minimally Symptomatic Chronic Subdural Hematoma: A Systematic Review and Meta-Analysis.
World Neurosurg
November 2024
Department of Neurosurgery, University of Missouri, Columbia, Missouri, USA.
Background: Conservative treatments for minimally symptomatic chronic subdural hematoma (cSDH) are debated, with surgery as the primary option.
Objective: To assess failure rates of a conservative approach for management of cSDH.
Methods: We searched PubMed, SCOPUS, Web of Science, and ClinicalTrials.
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