AI Article Synopsis
- The study investigates the links between dental infections and intracranial aneurysms by analyzing dental bacterial DNA and inflammation markers in patients.
- Results show that patients with deeper gingival pockets (≥ 6 mm) had significantly higher levels of certain bacteria, indicating a connection between dental health and aneurysm presence.
- The findings suggest that chronic dental infections, particularly periodontitis, are more prevalent among individuals with intracranial aneurysms, with about 43% of the studied patients showing severe gum issues.
Article Abstract
Objective: Dental bacterial DNA and bacterial-driven inflammation markers have previously been detected in intracranial aneurysm tissue samples. This study aimed (i) to assess the possible presence of dental infectious foci, (ii) and the possible association between typical odontogenic bacteria and clinical dental findings in patients undergoing pre-operative dental examination before surgical treatment of saccular intracranial aneurysm. Ninety patients with an intracranial aneurysm were recruited to the study, and the patients' teeth were routinely investigated. Clinical data and bacterial samples from the gingival pockets were collected from a subpopulation of 60 patients. Five typical dental pathogens and total bacteria amounts were measured from gingival samples using real-time quantitative PCR.
Results: The amounts of total bacterial and Fusobacterium nucleatum DNA were significantly higher in the patients with ≥ 6 mm gingival pockets than patients without them (p < 0.01 and p < 0.01, respectively). A total of 43% of patients with an aneurysm had gingival pockets of 6 mm or deeper. Dental infectious foci are fairly common in the Finnish population, with the prevalence of severe periodontitis being around 20%. The frequency of chronic dental infections, especially periodontitis seems to be higher in patients with intracranial aneurysm.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102815 | PMC |
| http://dx.doi.org/10.1186/s13104-018-3704-z | DOI Listing |
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