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Examining the role of Acinetobacter baumannii plasmid types in disseminating antimicrobial resistance.
NPJ Antimicrob Resist
January 2024
Australian Institute for Microbiology & Infection, University of Technology Sydney, Ultimo, NSW, Australia.
Acinetobacter baumannii is a Gram-negative pathogen responsible for hospital-acquired infections with high levels of antimicrobial resistance (AMR). The spread of multidrug-resistant A. baumannii strains has become a global concern.
View Article and Find Full Text PDFDissemination of clinical harboring the gene in Pakistan.
Front Microbiol
January 2025
Institute of Microbiology, University of Agriculture, Faisalabad, Pakistan.
Background: Colistin is an antibiotic used as a last resort to treat multidrug-resistant Gram-negative bacterial infections. Plasmid-mediated mobile colistin-resistant () genes in () are disseminated globally and are considered to be a major public health threat. This study aimed to determine the molecular characteristics of colistin-resistant isolates in clinical settings in Pakistan.
View Article and Find Full Text PDFDevelopment and validation of a UPLC-MS/MS method for simultaneous quantification of polymyxins and caspofungin in human plasma for therapeutic drug monitoring.
J Chromatogr B Analyt Technol Biomed Life Sci
January 2025
School of Pharmacy, Lanzhou University, Lanzhou 730030 China; Department of Pharmacy, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730030 China. Electronic address:
Objective: To develop a rapid, convenient, accurate, and low-residual-effect ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the determination of polymyxin B sulfate and colistin sulfate in the blood of patients with multidrug-resistant bacterial infections, as well as caspofungin acetate in the blood of patients with fungal infections, thus facilitating the rational use of antibiotics in clinical applications.
Methods: All analytes were diluted with 0.2 % aqueous formic acid, and plasma proteins were precipitated using acetonitrile.
Quaternary Ammonium Compounds: A New Driver and Hidden Threat for Prevalence in Hospital Wastewater and Human Feces.
Environ Sci Technol
January 2025
National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
The emergence of mobile colistin resistance gene has attracted global attention. The prevalence of -positive (MCRPEC) in humans largely decreased following the ban of colistin as an animal growth promoter in China. However, the prevalence of MCRPEC in the hospital environment and the relationship between disinfectants and remain unclear.
View Article and Find Full Text PDFResistome and plasmidome genomic features of mcr-1.1-harboring Escherichia coli: a One Health approach.
J Appl Microbiol
January 2025
Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, 90035-903, Brazil.
Aims: This study evaluated the phenotypic and genotypic traits of mcr-1.1-harboring Escherichia coli isolates from chickens, pigs, humans, and farm environments. The resistome and the mobile genetic elements associated with the spread of mcr-1.
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