AI Article Synopsis
- Stroke leads to the release of progenitor/stem cells from the bone marrow into the bloodstream and an increase in neuron specific enolase (NSE) levels.
- The study aimed to examine the activity of specific stem/progenitor cells in the first week after a stroke and assess the relationship between these cells and NSE levels as potential prognostic markers.
- Results indicated that higher NSE levels correlated with brain lesion volumes and initial stroke severity, suggesting NSE could be an important indicator of recovery outcomes after acute ischemic stroke.
Article Abstract
Stroke causes an efflux of various groups of progenitor/stem cells from bone marrow to bloodstream and a rise in neuron specific enolase (NSE) serum concentrations. The aim of this study was to identify activity of chosen stem/progenitor cells during first 7 days after stroke through correlations between these cells levels and NSE values. Additional goal was to confirm the role of NSE as a prognostic marker of ischemic stroke. Venous blood was collected repeatedly from 67 acute ischemic stroke patients and 15 control subjects, in order to assess NSE with ELISA, and CD45CD34 CD271+, CD45CD34 + CXCR4+, CD45CD34 + CXCR7+ and CD45CD34 CD133 + stem/progenitor cells by means of flow cytometry. Patients underwent repeated assessment with the National Ischemic Stroke Scale and modified Rankin Scale. Ischemic lesion volumes were assessed twice by MRI-DWI (day 1 and 5 ± 2). NSE correlated negatively with MFI levels of the CD45CD34 + CXCR7+ cells, and percentage levels of the CD45CD34 and CD45CD34 + CXCR4+ cells. NSE concentrations were significantly higher in patients compared to control subjects. NSE on day 2 positively correlated with lesion volume on both MRI. NSE on day 2 and 6-7 correlated positively with initial NIHSS scores, and on day 1 with mRS score on day 9. In conclusion, in this study NSE indicated some activity of the CD45CD34 + CXCR7+, CD45CD34 and CD45CD34 + CXCR4+ stem/progenitor cells in the first 7 days after ischemic stroke. Additionally, this study supports the thesis that NSE might be a valuable prognostic marker in acute ischemic stroke.
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| http://dx.doi.org/10.1016/j.neuint.2018.08.009 | DOI Listing |
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