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IMPACT OF PLANNED RESEARCH GAP YEAR ON UROLOGY RESIDENCY MATCH SUCCESS.
Urology
January 2025
Department of Urology, Loyola University Medical Center, Maywood, IL.
Objective: To assess the impact of a planned research gap year (RGY) on match outcomes and research productivity among urology residency applicants in the context of the highly competitive urology specialty and the new pass/fail format for the USMLE Step 1 exam.
Methods: We conducted an IRB-approved analysis of applicants to our program during the 2022-2023 and 2023-2024 application cycles. Data on demographics, medical school rank, having a home urology program, USMLE Step 1 scores, and ERAS research entries were collected.
Sepsis subtypes and differential treatment response to vitamin C: biological sub-study of the LOVIT trial.
Intensive Care Med
January 2025
Centre for Inflammation Research, Institute For Regeneration and Repair, University of Edinburgh, Edinburgh, Scotland, UK.
Purpose: We hypothesised that the biological heterogeneity of sepsis may highlight sepsis subtypes with differences in response to intravenous vitamin C treatment in the Lessening Organ Dysfunction with VITamin C (LOVIT) trial. Our aims were to identify sepsis subtypes and to test whether sepsis subtypes have differences in treatment effect to vitamin C and describe putative biological effects of vitamin C treatment.
Methods: We measured biomarkers of inflammation, at baseline and at 7 days post-randomisation, in 457/863 (53.
Investigating the point prevalence, types, severity, causes and predictors of vaccines administration errors during COVID-19 pandemic in Jordan.
PLoS One
January 2025
Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, The United Arab Emirates University, Al Ain, United Arab Emirates.
Article Synopsis
- A study in Jordan found a 2.4% prevalence of vaccine administration errors (VAEs) during the COVID-19 vaccination campaign, with various types of errors identified, including timing and dosing mistakes.
- Most errors were minor or moderate, and significant contributing factors included healthcare provider issues and higher error rates during peak vaccination times and in the Southern region.
- The findings highlight the need for more research and strategies to address VAEs to ensure effective immunization and patient safety.
Impact of mild hypercapnia on renal function after out-of-hospital cardiac arrest.
Resuscitation
December 2024
Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia; Department of Intensive Care, Austin Hospital, Heidelberg, Australia; Centre for Integrated Critical Care, The University of Melbourne, Melbourne, Australia.
Article Synopsis
- Acute kidney injury (AKI) is a common and serious problem following out-of-hospital cardiac arrest (OHCA), particularly influenced by post-resuscitation cardiogenic shock (CS).
- A study compared two groups of patients—those receiving targeted mild hypercapnia and those receiving targeted normocapnia—to see if higher carbon dioxide tension impacted AKI rates and other outcomes.
- Results showed that approximately 72.1% of patients developed AKI regardless of treatment, with CS significantly increasing the likelihood of AKI, but carbon dioxide levels did not alter this relationship.
Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (the PROMIZING study): update to the statistical analysis plan for a randomized controlled trial.
Trials
December 2024
Department of Critical Care, Keenan Research Centre, St Michael's Hospital, and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.
Background: We previously published the protocol and statistical analysis plan for a randomized controlled trial of Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: the PROMIZING study in Trials ( https://doi.org/10.1186/s13063-023-07163-w ).
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