We isolated Batai virus from the brain of a euthanized, 26-year-old, captive harbor seal with meningoencephalomyelitis in Germany. We provide evidence that this orthobunyavirus can naturally infect the central nervous system of a mammal. The full-genome sequence showed differences from a previously reported virus isolate from a mosquito in Germany.
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http://dx.doi.org/10.3201/eid2409.171829 | DOI Listing |
Methods Mol Biol
December 2024
Department of Pathology, The Sealy Institute for Vaccine Sciences, The Center for Biodefense and Emerging Infectious Diseases, The University of Texas Medical Branch at Galveston, Galveston, TX, USA.
Oropouche fever, a mosquito- or midge-borne emerging zoonotic disease endemic to South and Central America, manifests as a dengue-like acute febrile illness with occasional occurrences of meningitis or meningoencephalitis. The causative agent, Oropouche virus (OROV), belongs to the genus Orthobunyavirus within the family Peribunyaviridae. Its tripartite negative-sense RNA genome comprises small (S), medium (M), and large (L) segments, encoding structural N, Gn/Gc, and L proteins, respectively.
View Article and Find Full Text PDFMosquitoes are known to transmit different arthropod-borne viruses belonging to various virus families. The exogenous small interfering RNA pathway plays an important role in the mosquito defence against such virus infections, with Dicer-2 (Dcr2) as one of the key proteins that initiates the cleavage of viral dsRNAs into 21 nt long virus-derived small interfering RNAs. Previous data identified the importance of various motifs in Dcr2 for its small interfering RNA (siRNA)-mediated antiviral activity.
View Article and Find Full Text PDFJ Gen Virol
November 2024
Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana 70803, USA.
Bunyamwera virus (BUNV) is the prototypical member of the Bunyamwera serogroup within the genus. BUNV is transmitted by mosquito vectors of the genera , and and has historically circulated in East Africa, though the transmission has been observed in Argentina. BUNV has been identified as an agent of human and animal disease and has also been misdiagnosed as other agents.
View Article and Find Full Text PDFJ Virol
October 2024
Institute for Sustainable Plant Protection, National Research Council of Italy, Torino, Italy.
Viruses
August 2024
MRC-University of Glasgow-Centre for Virus Research, Garscube Campus, University of Glasgow, Glasgow G61 1QH, UK.
symbionts introduced into mosquitoes provide a highly effective dengue virus transmission control strategy, increasingly utilised in many countries in an attempt to reduce disease burden. Whilst highly effective against dengue and other positive-sense RNA viruses, it remains unclear how effective is against negative-sense RNA viruses. Therefore, the effect of on Bunyamwera virus (BUNV) infection in was investigated using Mel and AlbB, two strains currently used in releases for dengue control, as well as Au, a strain that typically persists at a high density and is an extremely efficient blocker of positive-sense viruses.
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