Neurotoxic disease can mimic many common neurologic disease states, including parkinsonism, myelopathy, neuropathy, and encephalopathy. Accurate diagnosis and appropriate treatment may result in a favorable outcome. This review highlights 5 areas of neurotoxicology for which there is an emerging understanding of disease processes or patterns of exposure, including 3 specific metal toxicities (manganism, zinc-induced copper deficiency, and cobalt-chromium neuropathy). Toxin-induced posterior reversible encephalopathy syndrome is more widely recognized and reported in association with an ever-growing list of drugs. Two new categories of street drugs, synthetic cathinones and cannabinoids, have been identified as public health threats due to their popularity, availability, and severity of toxicity.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829478 | PMC |
| http://dx.doi.org/10.1212/CPJ.0b013e318278be1e | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Z Scores, Standard Scores, and Composite Test Scores Explained.
Indian J Psychol Med
November 2021
Dept. of Clinical Psychopharmacology and Neurotoxicology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Patients may be assessed using a battery of tests where different tests yield scores in different units, where different tests have different minimum and maximum scores, and where higher or lower scores mean different things in different tests. Therefore, a composite test score cannot be obtained by simple addition or averaging of scores in the individual tests. However, if performances in individual tests are converted to Z scores, the Z scores can be added or averaged to yield a composite score that can be interpreted or processed using conventional statistical methods.
View Article and Find Full Text PDFQuantitative mapping of trimethyltin injury in the rat brain using magnetic resonance histology.
Neurotoxicology
May 2014
Center for In Vivo Microscopy, Department of Radiology, Duke University Medical Center, Durham, NC, United States.
The growing exposure to chemicals in our environment and the increasing concern over their impact on health have elevated the need for new methods for surveying the detrimental effects of these compounds. Today's gold standard for assessing the effects of toxicants on the brain is based on hematoxylin and eosin (H&E)-stained histology, sometimes accompanied by special stains or immunohistochemistry for neural processes and myelin. This approach is time-consuming and is usually limited to a fraction of the total brain volume.
View Article and Find Full Text PDFNeurotoxicology: Five new things.
Neurol Clin Pract
December 2012
Neurology and Emergency Medicine (LMT), Indiana University, Indianapolis; Neurology (NK), Mayo Clinic, Rochester, MN.
Neurotoxic disease can mimic many common neurologic disease states, including parkinsonism, myelopathy, neuropathy, and encephalopathy. Accurate diagnosis and appropriate treatment may result in a favorable outcome. This review highlights 5 areas of neurotoxicology for which there is an emerging understanding of disease processes or patterns of exposure, including 3 specific metal toxicities (manganism, zinc-induced copper deficiency, and cobalt-chromium neuropathy).
View Article and Find Full Text PDFCharacterizing children's exposures: beyond NHANES.
Neurotoxicology
August 2005
Organic Analytical Toxicology Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, Mailstop F17, 4770 Buford Highway, Atlanta, GA 30341-3724, USA.
Biomonitoring programs, such as those being conducted at the Centers for Disease Control and Prevention in conjunction with the National Health and Nutrition Examination Survey (NHANES), are of benefit to all disciplines of environmental public health. However, all programs have limitations, and like most things in science, "One size does not fit all." We point out some of these limitations, particularly those dealing with the amount of biological sample available from various age groups and the specificity of the exposure assessment.
View Article and Find Full Text PDFMonoamine oxidase expression during development and aging.
Neurotoxicology
January 2004
Department of Animal and Human Biology, University of Rome 1, Viale dell'Università 32, 00185 Rome, Italy.
Monoamine oxidase (MAO) isoenzymes play a major role in regulating the concentration of several bioactive amines, including serotonin and catecholamines. Both in the nervous system and in peripheral organs, MAOs can potentially modulate all the processes involving these bioactive amines. In the present article, we review some of the most significant articles published so far on changes in MAOs during development and aging.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!