[This corrects the article DOI: 10.1039/C5SC04108B.].
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http://dx.doi.org/10.1039/c6sc90078j | DOI Listing |
JAMA Netw Open
January 2025
Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora.
Importance: A recent advisory from the American Heart Association delineated the potential benefits of developmental care for hospitalized children with congenital heart disease (CHD) and a critical gap in research evaluating the association of such inpatient programs with neurodevelopmental outcomes.
Objective: To investigate associations between the Cardiac Inpatient Neurodevelopmental Care Optimization (CINCO) program interventions, delirium, and neurodevelopment in young children (newborn through age 2 years) hospitalized with CHD.
Design, Setting, And Participants: This cohort study used quality improvement data from inpatient cardiac units at a tertiary care children's hospital in the US.
Stat Med
February 2025
MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.
There is a growing number of Phase I dose-finding studies that use a model-based approach, such as the CRM or the EWOC method to estimate the dose-toxicity relationship. It is common to assume that all patients will have similar toxicity risk given the dose regardless of patients' individual characteristics. In many trials, however, some patients' covariates (e.
View Article and Find Full Text PDFStat Med
February 2025
Medical University of South Carolina, Charleston, South Carolina, USA.
This manuscript derives the allocation predictability measured by the correct guess probability and the probability of being deterministic for individual treatment assignments, as well as the averages of a randomization sequence, based on the treatment imbalance transition matrix and the conditional allocation probability. The methods described are applicable to restricted randomization designs that satisfy the following criteria: (1) two-arm equal allocation, (2) restriction of maximum tolerated imbalance, and (3) conditional allocation probability fully determined by the observed current treatment imbalance. Analytical results indicate that, for two-arm equal allocation trials, allocation predictability alternates by the odd/even sequence order of the treatment assignment.
View Article and Find Full Text PDFJpn J Ophthalmol
January 2025
Department of Ophthalmology and Visual Science, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Purpose: To investigate outcomes after trabeculotomy in Japanese patients with primary congenital glaucoma (PCG), and to identify risk factors for multiple glaucoma surgery procedures.
Study Design: Retrospective observational study.
Methods: Surgical outcomes were investigated in Japanese patients with PCG who underwent their first glaucoma surgery at Hiroshima University Hospital between January, 2006, and December, 2021.
Int Ophthalmol
January 2025
Department of Ophthalmology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, 215008, Jiangsu, China.
Purpose: Myopic choroidal neovascularization (CNV) is a common reason for visual impairment. This study investigated the clinical effects of repeated intravitreal injections of ranibizumab among patients with CNV secondary to pathologic myopia.
Methods: This study involved a single-center, non-randomized clinical prospective cohort research design including 39 patients with myopic CNV and a control group of 10 patients with cataract.
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