Comparison of anti- activities of the ancient plants and with antifungal drugs in species isolated from oral cavity.

Context: Medicinal plants have reportedly fewer side effects, compared to antifungal agents.

Aims: This study was designed to compare the anti- activity of two medicinal plants with two routine antifungal agents, used in the clinics, on species isolated from the oral cavity of the liver transplant patients.

Subjects And Methods: Anti- activities of ethanol extracts of leaf and unripe and ripe fruit (collected from south of Iran) versus nystatin and fluconazole were evaluated using CLSI M27-A3 standard method.

Results: The minimum inhibitory concentration (MIC) 90 values for , ripe, and unripe fruits in were 0.1 μg/mL, 25 μg/mL, and 0.1 μg/mL, and in were 0.05 μg/mL, 25 μg/mL, and 0.05 μg/mL, respectively. The MIC90 value for nystatin in both species was 0.035 μg/mL, but MIC90 value for fluconazole in was 0.5 μg/mL and in was 2 μg/mL.

Conclusion: Unripe fruits of and were found more effective than fluconazole on species. unripe fruit and leaf have potential anti- activity and can be considered as a new mouthwash agent to prevent and treat infections. Further studies regarding pharmacokinetics and toxicities of these extracts are needed for their use in humans.