Respiratory gated VMAT (volumetric modulated arc therapy) repeats rapid stop and go operations of a MLC (multileaf collimator) by turning the beam on and off by respiratory gating. The rapid stop and go operations of the MLC during respiratory gated irradiation may induce position error of the MLC and may affect output error and dose distribution. The purpose of this study was to clarify the relationship between the MLC position accuracy of the respiratory gated VMAT and the VMAT parameters. In the method, 1 arc, 2 arcs, and 4 arcs plan were created for the virtual target and irradiation was performed without the gated respiration and with the gated respiration. The respiratory gated system used a RPM (real-time position management system). The MLC position error, gap size error, and the MLC leaf speed were calculated from a log-file. In the histogram of the gap size error, the frequency of falling within the error range up to 0.2 mm was about 12 percentage points higher for the gated respiration. The MLC position error increased with increasing the MLC leaf speed. The correlation coefficient between the MLC leaf speed and the MLC position error exceeded 0.96, showing a strong correlation. Dose rate of VMAT parameters decreased with increasing arc number with the gated respiration and without the gated respiration. Gated irradiation was temporarily stopped, and it decreased by about 27% with respect to the dose rate without the gated respiration. The gantry rotation speed repeated the stop and re-rotation operations when gated irradiation was performed. For all arcs, the rotation speed decreased by about 30% compared with the rotation speed without the gated respiration. The pass rate of gamma analysis for each arc plan was about 95%. No effect on gated irradiation dose distribution was observed. Respiratory gated irradiation reduced dose rate change and gantry rotation speed of the VMAT. Reduction of the MLC leaf speed occurred, and the MLC position error and gap size error decreased. The MLC positional accuracy was secured, and it was confirmed that there was no effect on dose distribution by the respiratory gated VMAT.
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http://dx.doi.org/10.11323/jjmp.38.1_2 | DOI Listing |
Respir Physiol Neurobiol
December 2024
Department of Pathophysiology Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Slovakia. Electronic address:
Background: Allergic rhinitis (AR) is a common cause of chronic cough, linked to dysregulated airway C- and Aδ-fibres through inflammatory mediators. Despite the limited efficacy of current antitussive therapies, recent studies show that the Na1.7 inhibitor can block cough in naïve guinea pigs.
View Article and Find Full Text PDFJAMA Netw Open
December 2024
Influenza Division, National Center for Immunization and Respiratory Diseases, US Centers for Disease Control and Prevention, Atlanta, Georgia.
Importance: Increasing the understanding of vaccine effectiveness (VE) against levels of severe influenza in children could help increase uptake of influenza vaccination and strengthen vaccine policies globally.
Objective: To investigate VE in children by severity of influenza illness.
Design, Setting, And Participants: This case-control study with a test-negative design used data from 8 participating medical centers located in geographically different US states in the New Vaccine Surveillance Network from November 6, 2015, through April 8, 2020.
Int J Med Robot
December 2024
School of Automation, Nanjing University of Information Science and Technology, Nanjing, China.
Background: Percutaneous puncture procedures, guided by image-guided robotic-assisted intervention (IGRI) systems, are susceptible to disruptions in patients' respiratory rhythm due to factors such as pain and psychological distress.
Methods: We developed an IGRI system with a coded structured light camera and a binocular camera. Our system incorporates dual-pathway deep learning networks, combining convolutional long short-term memory (ConvLSTM) and point long short-term memory (PointLSTM) modules for real-time respiratory signal monitoring.
Lancet Infect Dis
December 2024
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Background: Pneumococcal conjugate vaccines (PCVs) that are ten-valent (PCV10) and 13-valent (PCV13) became available in 2010. We evaluated their global impact on invasive pneumococcal disease (IPD) incidence in all ages.
Methods: Serotype-specific IPD cases and population denominators were obtained directly from surveillance sites using PCV10 or PCV13 in their national immunisation programmes and with a primary series uptake of at least 50%.
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