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The impact of single-nucleotide polymorphisms on liver stiffness and controlled attenuation parameter in patients treated with direct-acting antiviral drugs for hepatitis C infection.
Biomed Rep
February 2022
Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan.
Article Synopsis
- SNPs in certain genes (like PLIN3, TLL1, and IL28) are linked to the risk of liver issues in hepatitis C patients.
- A study measured liver stiffness and steatosis in 77 patients before and after direct-acting antiviral treatment, focusing on different SNP genotypes.
- Results showed significant changes in liver stiffness for specific genotypes, suggesting that these SNPs could help predict liver health improvements post-treatment.
Association of TNFRSF1A and IFNLR1 Gene Polymorphisms with the Risk of Developing Breast Cancer and Clinical Pathologic Features.
Biochem Genet
October 2021
Department of Cell Biology, Embryology and Genetics (BEG), School of Biological Sciences (CCB), Universidade Federal de Santa Catarina (UFSC), Florianópolis, 88040-900, Brazil.
Several genes have been associated with breast cancer (BC) susceptibility. The tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A), and interferon lambda receptor 1 (IFNLR1) genes encode receptors that mediate the action of inflammatory cytokines. Previous studies have demonstrated the association of the variants rs1800693 (TNFRSF1A) and rs4649203 (IFNLR1) with some inflammatory diseases.
View Article and Find Full Text PDFInterleukin 28 Polymorphisms and Hepatocellular Carcinoma Development after Direct Acting Antiviral Therapy for Chronic Hepatitis C.
J Gastrointestin Liver Dis
December 2019
Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Gastroenterology and Hepatology Unit, S. Orsola- Malpighi University Hospital, Bologna, Italy; Centre for Applied Biomedical Research (CRBA), University of Bologna, S. Orsola- Malpighi University Hospital, Bologna, Italy.
Background And Aims: Cirrhotic patients with hepatitis C virus (HCV) infection remain at risk of developing hepatocellular carcinoma (HCC) even after the sustained virologic response (SVR). We aimed to evaluate whether the IL28 (rs12979860) single nucleotide polymorphism (SNP) may constitute a predisposing genetic factor and to identify the SVR patients at risk of HCC.
Methods: Two hundred patients undergoing DAAs treatment for chronic hepatitis C with advanced fibrosis (F3- F4) were consecutively enrolled.
Correlation between interleukin-28 gene polymorphism with interleukin-28 cytokine levels and viral genotypes among HCV patients in Yazd, Iran.
BMC Res Notes
September 2019
Gastroentrology Department, Shahid Sadoughi Hospital, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Objectives: Recent studies using genome-wide association studies (GWAS) have shown the strong association between polymorphisms near the interleukin-28B (IL-28B) gene and spontaneous clearance of hepatitis C virus (HCV). The present study was designed to evaluate the association of interleukin-28 gene polymorphism with interleukin-28 cytokine levels in different viral genotypes among HCV patients in Yazd, Iran.
Result: The most prevalent genotype in chronic cases was genotype 3a, and the lowest one was 2/3a.
Interleukin-28 Polymorphism: Ethnic variations and the response to chronic hepatitis C treatment in Malaysia.
Med J Malaysia
August 2018
Hospital Sultanah Bahiyah, Clinical Research Centre, Alor Setar, Kedah, Malaysia.
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