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Exploring the causal effect of complement and IgA nephropathy-a Mendelian randomization study.
Ren Fail
December 2024
Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
IgA nephropathy, one of the most common primary glomerulonephritis worldwide, is still under investigation for its precise etiology. The widely accepted theory is the 'four-hit model' and subsequent complement and inflammatory responses. Recent studies have reported correlations between specific complement components and IgA nephropathy.
View Article and Find Full Text PDFInterrogating post-transplant donor HLA-specific antibody characteristics and effector functions using clinical bead assays.
Hum Immunol
November 2024
Department of Immunology, Duke University School of Medicine, Durham, NC, USA; Department of Surgery, Duke University School of Medicine, Durham, NC, USA. Electronic address:
Article Synopsis
- Single antigen bead (SAB) assays are the main technique for detecting donor-specific HLA antibodies after a transplant, but there's a lack of direct comparisons between traditional and modified methods for better monitoring.
- A study analyzed 251 post-transplant DSA from 91 serum samples using different treatments to determine the effectiveness of detecting antibodies; they found that some DSAs correlate with high IgG MFI values, indicating stronger antibody presence.
- The findings suggest that both the 1:16 dilution and C1q tests are effective indicators for detecting DSAs, with C1q positively correlating with total IgG levels, and modifications to SAB assays may help refine testing and interpretation of results
Direct antiglobulin test type, red blood cell distribution width, and estimated glomerular filtration rate for early prediction of in-hospital mortality of patients with COVID-19.
Comput Struct Biotechnol J
December 2024
Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, 150 Ximen Road, Linhai, Taizhou, Zhejiang Province, China.
Article Synopsis
- The study aimed to explore how COVID-19 correlates with the direct antiglobulin test (DAT) results, focusing on developing a predictive model for in-hospital mortality based on DAT types among patients with COVID-19.
- The analysis involved 502 patients tested for DAT, revealing that those who were DAT-positive had a higher rate of confirmed COVID-19 cases and worse clinical indicators compared to DAT-negative patients.
- Key findings indicated that DAT-positive patients had higher mortality and comorbidity scores, with a predictive model utilizing DAT type, red blood cell distribution width (RDW), and estimated glomerular filtration rate (eGFR) providing significant predictive accuracy for in-hospital mortality risk.
The causal impact of complement C3d receptor 2 on head and neck cancer microenvironment and its implications for immunotherapy response prediction.
Heliyon
April 2024
Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.
Article Synopsis
- The study explores the complex immune environment in head and neck cancer (HNC) by analyzing immune cell subpopulations and their associated genes using tumor RNA sequencing data from two cohorts (192 in-house, 546 TCGA-HNSC).
- Key findings reveal various tumor immune phenotypes that either help protect against HNC or raise the risk for it, while specific genetic variations (SNPs) in immune cells were linked to HNC development.
- The research emphasizes the potential of targeting the Complement C3d Receptor 2 (CR2) gene, which is related to better tumor prognosis and stronger immune responses, suggesting that therapies focusing on CR2 could improve treatment outcomes for HNC patients.
Gliosis-dependent expression of complement factor H truncated variants attenuates retinal neurodegeneration following ischemic injury.
J Neuroinflammation
February 2024
Department of Physiological Genomics, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.
Inherited, age-related, and acute retinal diseases are often exacerbated by an aberrant or excessive activity of the complement system. Consequently, cells not directly affected by an acute event or genetic variants may degenerate, resulting in enhanced visual impairment. The therapeutic potential of supplementation of complement factor H (FH), a key regulator of the complement cascade, is therefore particularly promising in the context of retinal diseases caused by complement activation.
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