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Stoss therapy using fortified biscuit for vitamin D-deficient children: a novel treatment. | LitMetric

AI Article Synopsis

  • The study assessed the effectiveness of stoss therapy using fortified biscuits compared to traditional vitamin D supplements in children aged 30-72 months who are vitamin D deficient.
  • A randomized trial involved 108 children divided into three groups receiving either fortified biscuits, vitamin D capsules, or ampoules over three weeks.
  • Results showed all treatments increased vitamin D levels, but the biscuit group had a significant difference when compared to the ampoule group, suggesting fortified biscuits could improve compliance in children reluctant to take pills.

Article Abstract

Background: To evaluate the efficacy of stoss therapy using fortified biscuit for vitamin D-deficient children.

Methods: A total of 108 children aged 30-72 months with vitamin D deficiency were studied in a randomized single-blind clinical trial. The deficient children were assigned to three groups, namely, vitamin D-fortified biscuit (BG), capsule vitamin D (CG), and ampoule vitamin D (AG). Capsules and biscuits containing 50,000 IU of cholecalciferol were consumed twice per week for 3 consecutive weeks. Ampoules with 300,000 IU of cholecalciferol were injected intramuscularly in a single dose. Three weeks after treatment, serum 25(OH)D concentrations were measured, and the three groups were compared.

Results: Each method of treatment could increase the mean serum 25(OH)D concentration to optimal level. Serum 25(OH)D concentrations ≥100 ng/mL were observed in six children, including four from AG and two from CG (P = 0.09). The comparison of the mean serum 25(OH)D concentrations after treatment showed between ampoule and capsule (P = 0.3) and capsule and biscuit (P = 0.62) were insignificant; however, the ampoule and biscuit groups differed significantly (P = 0.012).

Conclusion: Stoss therapy using fortified biscuit may be an effective way to improve compliance in children who cannot take capsules without adverse effects and may also be recommended for prevention purposes.

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Source
http://dx.doi.org/10.1038/s41390-018-0135-4DOI Listing

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