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Clozapine-Associated Aspiration During Electroconvulsive Therapy.
J ECT
June 2019
Department of Psychiatry, Massachusetts General Hospital, Boston, MA.
Clozapine-induced gastric hypomotility (CIGH) is an underreported, underrecognized effect from high-dose clozapine. In this report, we present a patient with treatment refractory schizophrenia receiving high-dose clozapine who aspirated during general anesthesia for electroconvulsive therapy. To our knowledge, this is the first report of aspiration under general anesthesia as a result of CIGH and highlights the potential dangers high-dose clozapine can pose on patients undergoing electroconvulsive therapy with unrecognized CIGH.
View Article and Find Full Text PDFClozapine-Associated Aspiration Pneumonia: Case Series and Review of the Literature: Reply.
Psychosomatics
April 2019
VA Boston Healthcare System, Brockton, MA 02301 (RJM).
Clozapine-Associated Aspiration Pneumonia: Case Series and Review of the Literature.
Psychosomatics
March 2019
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA.
Clozapine-associated pneumonia and respiratory arrest secondary to severe constipation.
Med Sci Law
April 2014
St Andrew's Healthcare, Birmingham, UK.
Clozapine is often the drug of choice within patients suffering from treatment-resistant paranoid schizophrenia. It has a complex side effects profile which includes potentially fatal agranulocytosis. Clozapine has also become increasingly associated with a range of other side effects including constipation and pneumonia.
View Article and Find Full Text PDFGastrointestinal hypomotility: an under-recognised life-threatening adverse effect of clozapine.
Forensic Sci Int
March 2011
Toxicology Unit, Department of Clinical Biochemistry, King's College Hospital NHS Foundation Trust, Denmark Hill, London SE5 9RS, UK.
Aim: To highlight some problems that may occur when investigating clozapine-associated deaths including (i) that death may be related to gastrointestinal hypomotility and (ii) that post-mortem blood clozapine and norclozapine concentrations may not reflect ante-mortem concentrations.
Case Reports: A 41-year-old male died 40 min after admission to hospital as a result of aspiration complicating severe, clozapine-induced constipation. At post-mortem the small bowel was dilated and contained bloodstained mucus, particularly within the jejunum.
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