AI Article Synopsis
- Animals exhibit a natural behavior called sodium (or salt) appetite, where they seek out and consume salt when their sodium levels are low, even if they usually dislike it at normal sodium levels.
- The subfornical organ (SFO) in the brain is crucial for detecting sodium deficiency and triggering the desire to eat salt, impacting various bodily functions like cardiovascular health and energy balance.
- Recent research highlights the neurochemical mechanisms and brain circuits involved in the SFO's role in regulating salt appetite, contributing to our understanding of how the body maintains sodium homeostasis.
Article Abstract
To maintain sodium homeostasis, animals will readily seek and ingest salt when salt-depleted, even at concentrations that they typically find aversive when sodium replete. This innate behaviour is known as sodium (or salt) appetite. Salt appetite is subserved by a conserved brain network that senses sodium need and promotes the ingestion of salty substances when sodium-deficient. The subfornical organ (SFO) is a circumventricular organ that has diverse roles encompassing cardiovascular regulation, energy balance, immune responses, reproduction, and hydromineral balance. The SFO acts as a central sensor of sodium need and is essential for the generation of salt appetite. In this review, we discuss recent findings on the neurochemical and circuit-level organisation of the SFO in the context of sodium appetite. This article is part of the Special Issue entitled 'Hypothalamic Control of Homeostasis'.
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| http://dx.doi.org/10.1016/j.neuropharm.2018.08.012 | DOI Listing |
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