Purpose: The study illustrates how a renewed approach to medical physics, Medical Physics 3.0 (MP3.0), can identify performance decrement of digital radiography (DR) systems when conventional Medical Physics 1.0 (MP1.0) methods fail.
Methods: MP1.0 tests included traditional annual tests plus the manufacturer's automated Quality Assurance Procedures (QAP) of a DR system before and after a radiologist's image quality (IQ) complaint repeated after service intervention. Further analysis was conducted using nontraditional MP3.0 tests including longitudinal review of QAP results from a 15-yr database, exposure-dependent signal-to-noise (SNR ), clinical IQ, and correlation with the institutional service database. Clinical images were analyzed in terms of IQ metrics by the Duke University Clinical Imaging Physics Group using previously validated software.
Results: Traditional metrics did not indicate discrepant system performance at any time. QAP reported a decrease in contrast-to-noise ratio (CNR) after detector replacement, but remained above the manufacturer's action limit. Clinical images showed increased lung noise (Ln), mediastinum noise (Mn), and subdiaphragm-lung contrast (SLc), and decreased lung gray level (Lgl) following detector replacement. After detector recalibration, QAP CNR improved, but did not return to previous levels. Lgl and SLc no longer significantly differed from before detector recalibration; however, Ln and Mn remained significantly different. Exposure-dependent SNR documented the detector operating within acceptable limits 9 yr previously but subsequently becoming miscalibrated sometime before four prior annual tests. Service records revealed catastrophic failure of the computer containing the original detector calibration from 11 yr prior. It is likely that the incorrect calibration backup file was uploaded at that time.
Conclusions: MP1.0 tests failed to detect substandard system performance, but MP3.0 methods determined the root cause of the problem. MP3.0 exploits the wealth of data with more sensitive performance indicators. Data analytics are powerful tools whose proper application could facilitate early intervention in degraded system performance.
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http://dx.doi.org/10.1002/acm2.12425 | DOI Listing |
JAMA Netw Open
January 2025
Alzheimer Center Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands.
Importance: Baseline cerebral microbleeds (CMBs) and APOE ε4 allele copy number are important risk factors for amyloid-related imaging abnormalities in patients with Alzheimer disease (AD) receiving therapies to lower amyloid-β plaque levels.
Objective: To provide prevalence estimates of any, no more than 4, or fewer than 2 CMBs in association with amyloid status, APOE ε4 copy number, and age.
Design, Setting, And Participants: This cross-sectional study used data included in the Amyloid Biomarker Study data pooling initiative (January 1, 2012, to the present [data collection is ongoing]).
Neuroinformatics
January 2025
Translational Neuroimaging Group, Center for Image Sciences, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Blood flow velocity in the cerebral perforating arteries can be quantified in a two-dimensional plane with phase contrast magnetic imaging (2D PC-MRI). The velocity pulsatility index (PI) can inform on the stiffness of these perforating arteries, which is related to several cerebrovascular diseases. Currently, there is no open-source analysis tool for 2D PC-MRI data from these small vessels, impeding the usage of these measurements.
View Article and Find Full Text PDFRadiat Environ Biophys
January 2025
Department of Environmental Health Sciences, #820-11, Slot, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, 4301 W. Markham Str, Little Rock, AR, 72205, USA.
Most studies on the effects of galactic cosmic rays (GCR) have relied on terrestrial irradiation using spatially homogeneous dose distributions of mono-energetic beams comprised of one ion species. Here, we exposed mice to novel beams that more closely mimic GCR, namely, comprising poly-energetic ions of multiple species. Six-month-old male and female C57BL/6J mice were exposed to 0 Gy, 0.
View Article and Find Full Text PDFNano Lett
January 2025
NMR Signal Enhancement Group, Max Planck Institute for Multidisciplinary Sciences, 37077 Göttingen, Germany.
Deuterium (H) MRI is an emerging tool for noninvasive imaging. We explore the integration of H MRI with deuterated multifunctional nanopolymers for deuterated particle imaging (DPI). To this end, amine-terminated G5-polyamidoamine (PAMAM) dendrimers were labeled with deuterated acetyl surface groups, leading to highly H-loaded bioparticles, making them ideal for imaging studies.
View Article and Find Full Text PDFNanotoxicology
January 2025
Institute of Physics Belgrade, University of Belgrade, Belgrade, Serbia.
In this study, we investigated the cytotoxic effect of highly soluble dextran-coated CeO nanoparticles on human fetal lung fibroblasts MRC-5. We examined individual nanoparticle-treated cells by Raman spectroscopy and analyzed Raman spectra using non-negative principal component analysis and k-means clustering. In this way, we determined dose-dependent differences between treated cells, which were reflected through the intensity change of lipid, phospholipid and RNA-related Raman modes.
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