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Population Pharmacokinetics and Pharmacodynamics of Sotalol Following Expedited Intravenous Loading in Patients With Atrial Arrhythmias.
CPT Pharmacometrics Syst Pharmacol
January 2025
Division of Clinical Pharmacology, Department of Pediatrics, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, Utah, USA.
Sotalol, a class III antiarrhythmic agent, is used to maintain sinus rhythm in patients with atrial fibrillation or atrial flutter (AFIB/AFL). Despite its efficacy, sotalol's use is limited by its potential to cause life-threatening ventricular arrhythmias due to QT interval prolongation. Traditionally, sotalol administration required hospitalization to monitor these risks.
View Article and Find Full Text PDFSafety and feasibility of intravenous sotalol loading for the prevention of ventricular arrhythmias.
J Interv Card Electrophysiol
October 2024
Division of Cardiology, Department of Medicine, Northwestern University, Chicago, IL, USA.
Background: The use of intravenous (IV) sotalol loading following recent U.S. Food and Drug Administration (FDA) approval of a 1-day loading protocol has reduced the obligatory 3-day hospital stay for sotalol initiation when given orally.
View Article and Find Full Text PDFExpedited loading with intravenous sotalol is safe and feasible-primary results of the Prospective Evaluation Analysis and Kinetics of IV Sotalol (PEAKS) Registry.
Heart Rhythm
July 2024
Division of Cardiovascular Medicine, University of Utah Health, Salt Lake City, Utah.
Article Synopsis
- A study evaluated the use of intravenous (IV) sotalol for safely and quickly loading patients with atrial fibrillation, contrasting it with the traditional oral loading process that often requires a 3-day hospital stay.
- The research involved 167 patients, mainly older adults, and found that 99% were admitted for sotalol initiation, achieving a short average hospital stay of 1.1 days with few adverse effects.
- Results suggest that IV sotalol is a safe and efficient alternative for treating atrial arrhythmias; however, more research is necessary to determine the optimal hospital monitoring duration.
Single- and multiple-dose pharmacokinetics of sotalol hydrochloride in healthy cats.
J Vet Cardiol
February 2024
Department of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, 1060 William Moore Drive, Raleigh, NC, 27607, USA.
Introduction/objectives: The objective of this study was to describe the single- and multiple-dose pharmacokinetics and urinary elimination of sotalol in healthy cats.
Animals: Six adult purpose-bred cats MATERIALS AND METHODS: Cats were administered 2 mg sotalol/kg body weight as a single intravenous bolus and as a single oral dose in a randomized crossover study with a two-week washout period. The same cats then received 3 mg sotalol/kg orally every 12 h for two weeks.
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