Adherent cells round up before division but it is unclear how detachment is regulated by the cell cycle. In this issue, Jones et al. (2018. https://doi.org/10.1083/jcb.201802088) find the kinase CDK1 maintains adhesion during interphase by phosphorylating integrin adhesome proteins, including the formin FMNL2, and loss of this function of CDK1 activity in G2 triggers adhesion disassembly.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122993 | PMC |
| http://dx.doi.org/10.1083/jcb.201808067 | DOI Listing |
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