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Crit Care Med
September 2018
Division of Medicine, Akershus University Hospital, Lørenskog, Norway, and Center for Heart Failure Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Anestesia e Rianimazione, Azienda-Ospedaliero Universitaria S. Luigi Gonzaga, Orbassano, Italy, and Dipartimento di Oncologia, Università degli Studi di Torino, Turin, Italy; Department of Cardiovascular Research, IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy; Department of Cardiovascular Research, IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri," Milan, Italy; Division of Medicine, Akershus University Hospital, Lørenskog, Norway, and Center for Heart Failure Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Secretoneurin in Sepsis: Is It the Brain?
Crit Care Med
September 2018
Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria.
Prognostic Value of Secretoneurin in Patients With Severe Sepsis and Septic Shock: Data From the Albumin Italian Outcome Sepsis Study.
Crit Care Med
May 2018
Division of Medicine, Akershus University Hospital, Lørenskog, Norway and Center for Heart Failure Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Objectives: Secretoneurin directly influences cardiomyocyte calcium handling, and circulating secretoneurin levels seem to improve risk prediction in patients with myocardial dysfunction by integrating information on systemic stress, myocardial function, and renal function. Accordingly, in this study, we hypothesized that secretoneurin would improve risk prediction in patients with sepsis and especially in patients with septic shock as these patients are more hemodynamically unstable.
Design: Multicenter, interventional randomized clinical trial.
Prognostic Value of Secretoneurin in Critically Ill Patients With Infections.
Crit Care Med
October 2016
1Division of Medicine, Akershus University Hospital, Lørenskog, Norway.2Center for Heart Failure Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.3Department of Medical Sciences, Uppsala University, Uppsala, Sweden.4Institute for Experimental Medical Research, Oslo University Hospital, Oslo, Norway.5Bioinformatics core facility, University of Oslo and Oslo University Hospital, Oslo, Norway.6Department of Intensive Care Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.7Department of Intensive Care Medicine, Bern University Hospital, University of Bern, Bern, Switzerland.8Department of Intensive Care Medicine, Tampere University Hospital, Tampere, Finland.9Intensive Care Medicine, Kuopio University Hospital, Kuopio, Finland.
Objectives: Secretoneurin is produced in neuroendocrine cells, and the myocardium and circulating secretoneurin levels provide incremental prognostic information to established risk indices in cardiovascular disease. As myocardial dysfunction contributes to poor outcome in critically ill patients, we wanted to assess the prognostic value of secretoneurin in two cohorts of critically ill patients with infections.
Design: Two prospective, observational studies.
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