The method of incorporating the sources of parameter uncertainty is crucial when conducting probabilistic analysis for service limit state (SLS) design of a deep foundation. This paper describes the method of using Monte Carlo simulation for probabilistic analyses and for calibration of resistance factors of drilled shafts at SLS. The paper presents discussions on the finding of an impossible case, where the different combinations of load, variability of soil strength and target probability of failure made it impossible to calibrate the SLS resistance factors. Resistance factors for drilled shafts in shale are introduced, and were found to be responsive to load levels. The higher load level, the lower the resistance factor. These findings help smooth the transition from allowable stress design to load and resistance factor design for geotechnical engineers.
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http://dx.doi.org/10.1016/j.heliyon.2018.e00727 | DOI Listing |
Alzheimers Dement
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Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.
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Human Genetics Laboratory, Institute of Natural Sciences, Federal University of Alfenas (UNIFAL-MG), Alfenas, 37130-001, MG, Brazil.
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Department of Gastrointestinal Surgery, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Chemotherapy resistance is a great challenge in the treatment of gastric cancer (GC), so it is urgent to explore the prognostic markers of chemoresistance. PUF60 (Poly (U)-binding splicing factor 60) is a nucleic acid-binding protein that has been shown to regulate transcription and link to tumorigenesis in various cancers. However, its biological role and function in chemotherapy resistance of GC is unclear.
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Department of Urology, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
Clear cell renal cell carcinoma (ccRCC) is one of the most common and aggressive malignancies of the urinary system. Despite being the first-line treatment for advanced ccRCC, vascular endothelial growth factor receptor inhibitors (VEGFRis) face significant limitations due to both initial and acquired resistance, which impede complete tumor eradication. Using a CRISPR/Cas9 library screening approach, was identified as a resistance-associated gene for three prevalent VEGFRis (Sunitinib, Axitinib, and Sorafenib).
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Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Dysregulated energy metabolism, particularly lipid metabolism disorders, has been identified as a key factor in the development of diabetic cardiomyopathy (DCM). Sirtuin 2 (SIRT2) is a deacetylase involved in the regulation of metabolism and cellular energy homeostasis, yet its role in the progression of DCM remains unclear. We observed significantly reduced SIRT2 expression in DCM model mice.
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