Aim: To investigate antimicrobial resistance mechanisms in a cluster of colistin-resistant .
Methods: Antimicrobial susceptibility was tested by disk diffusion and broth microdilution. Whole-genome sequencing and genome analysis were performed.
Results: The eight colistin-resistant isolates belonged to three different clones (ST11, 14 and 231). and genes from lipid modification pathway had novel (R157S in and Q319R in ) and rare mutations (V39L, R152H, S260L and A279G in ). Several substitutions were also identified in , , and genes. The genes were absent in all isolates. Isolates had variants from existing classes of gene.
Conclusion: Complex combination of mutations might have led to colistin resistance, which suggests that continuous surveillance of molecular mechanisms is required.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088269 | PMC |
| http://dx.doi.org/10.4155/fsoa-2018-0011 | DOI Listing |
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