AI Article Synopsis
- NMDA receptors (NMDARs) play a key role in long-term potentiation (LTP) across various central synapses, impacting sensory processing and perception.
- Research shows that inhibiting NMDAR-dependent LTP can lead to pain relief in animals with chronic pain, suggesting a significant link between these receptors and pain mechanisms.
- Studying the signaling pathways involved in NMDAR LTP could lead to new strategies for treating chronic pain.
Article Abstract
Since the discovery of NMDA receptor (NMDAR) dependent long-term potentiation (LTP) in the hippocampus, many studies have demonstrated that NMDAR dependent LTP exists throughout central synapses, including those involved in sensory transmission and perception. NMDAR LTP has been reported in spinal cord dorsal horn synapses, anterior cingulate cortex and insular cortex. Behavioral, genetic and pharmacological studies show that inhibiting or reducing NMDAR LTP produced analgesic effects in animal models of chronic pain. Investigation of signalling mechanisms for NMDAR LTP may provide novel targets for future treatment of chronic pain.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420414 | PMC |
| http://dx.doi.org/10.1007/s11064-018-2614-8 | DOI Listing |
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