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Long-Term Effects of Unmodified 50 nm ZnO in Mice. | LitMetric

Long-Term Effects of Unmodified 50 nm ZnO in Mice.

Biol Trace Elem Res

College of Animal Science and Veterinary Medicine, Henan University of Science and Technology, No. 263 Kaiyuan Road, Luoyang, Henan, 471023, People's Republic of China.

Published: June 2019

AI Article Synopsis

Article Abstract

Nanometer zinc oxide (nano-ZnO) is widely used in many kinds of fields. However, information about the toxicity and toxic mechanism of nano-ZnO is limited. The aims of this study were to investigate the long-term toxic effects of unmodified 50 nm ZnO administered by gavage in mice. After 90 days, hematological parameters, hepatic and renal functions, and oxidative and anti-oxidative status were measured. Pathological damages in livers, kidneys, and other tissues were also examined by hematoxylin and eosin (H&E) staining. The results showed that oral nano-ZnO exposure induced anemia and damages to liver and kidney, influenced the antioxidant system, and impacted functions of liver and kidney in mice after a 90-day exposure. The main cause for oxidative stress in vivo induced by nano-ZnO might be hydroxyl free radical. The lowest observed adverse effect level (LOAEL) was 40 mg/kg·bw, and the livers, kidneys, lungs, pancreas, and gastrointestinal tracts are the target organs.

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Source
http://dx.doi.org/10.1007/s12011-018-1477-9DOI Listing

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