In this paper, a detailed analysis of microwave (MW) scattering from a three-dimensional (3D) anthropomorphic human head model is presented. It is the first time that the finite-element method (FEM) has been deployed to study the MW scattering phenomenon of a 3D realistic head model for brain stroke detection. A major contribution of this paper is to add anatomically more realistic details to the human head model compared with the literature available to date. Using the MRI database, a 3D numerical head model was developed and segmented into 21 different types through a novel tissue-mapping scheme and a mixed-model approach. The heterogeneous and frequency-dispersive dielectric properties were assigned to brain tissues using the same mapping technique. To mimic the simulation set-up, an eight-elements antenna array around the head model was designed using dipole antennae. Two types of brain stroke (haemorrhagic and ischaemic) at various locations inside the head model were then analysed for possible detection and classification. The transmitted and backscattered signals were calculated by finding out the solution of the Helmholtz wave equation in the frequency domain using the FEM. FE mesh convergence analysis for electric field values and comparison between different types of iterative solver were also performed to obtain error-free results in minimal computational time. At the end, specific absorption rate analysis was conducted to examine the ionization effects of MW signals to a 3D human head model. Through computer simulations, it is foreseen that MW imaging may efficiently be exploited to locate and differentiate two types of brain stroke by detecting abnormal tissues' dielectric properties. A significant contrast between electric field values of the normal and stroke-affected brain tissues was observed at the stroke location. This is a step towards generating MW scattering information for the development of an efficient image reconstruction algorithm.
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http://dx.doi.org/10.1098/rsos.180319 | DOI Listing |
Transl Psychiatry
January 2025
Laboratory of Exercise and Neurobiology, School of Physical Education and Sports Science, South China Normal University, Guangzhou, 510006, Guangdong, China.
Repeated closed-head injuries (rCHI) from activities like contact sports, falls, military combat, and traffic accidents pose a serious risk due to their cumulative impact on the brain. Often, rCHI is not diagnosed until symptoms of irreversible brain damage appear, highlighting the need for preventive measures. This study assessed the prophylactic efficacy of remote photobiomodulation (PBM) targeted at the lungs against rCHI-induced brain injury and associated behavioral deficits.
View Article and Find Full Text PDFJ Craniomaxillofac Surg
January 2025
Department of Diagnostic and Interventional Radiology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
The potential of large language models (LLMs) in medical applications is significant, and Retrieval-augmented generation (RAG) can address the weaknesses of these models in terms of data transparency and scientific accuracy by incorporating current scientific knowledge into responses. In this study, RAG and GPT-4 by OpenAI were applied to develop GuideGPT, a context aware chatbot integrated with a knowledge database from 449 scientific publications designed to provide answers on the prevention, diagnosis, and treatment of medication-related osteonecrosis of the jaw (MRONJ). A comparison was made with a generic LLM ("PureGPT") across 30 MRONJ-related questions.
View Article and Find Full Text PDFReprod Toxicol
January 2025
Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain; Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Alimentaciò, Nutrició, Desenvolupament i Salut Mental ANUT-DSM, Reus, Spain; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain.
This study aimed to investigate the association between estimated dietary intake of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) and human sperm quality. This study cross-sectionally assessed the associations between estimated dietary intake of PCDD/Fs and sperm quality parameters in 200 participants aged 18-40 years from the Led-Fertyl study. Linear regression models, accounting for potential confounding variables, were employed to evaluate the relationships.
View Article and Find Full Text PDFRadiother Oncol
January 2025
Department of Nursing, Shanghai Proton and Heavy Ion Center, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai 201315 China. Electronic address:
Background And Purpose: Few studies have examined the factors associated with xerostomia during proton and carbon ion radiotherapy for head and neck cancer (HNC), which are reported to have fewer toxic effects compared to traditional photon-based radiotherapy. This study aims to evaluate the performance of machine learning approaches in predicting grade 2 + xerostomia in adults with HNC receiving proton and carbon ion radiotherapy.
Materials And Methods: A retrospective study involving 1,769 adults with HNC who completed proton or carbon ion radiotherapy was conducted.
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