https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=30108890&retmode=xml&tool=Litmetric&email=readroberts32@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09 3010889020201001
2040-2503892017Sep01MedChemCommMedchemcommStructure-optimized dihydropyranoindole derivative GIBH-LRA002 potentially reactivated viral latency in primary CD4+ T lymphocytes of chronic HIV-1 patients.180618091806-180910.1039/c7md00327gBased on structure modification and a high-throughput Jurkat-Lat cell screening model, we found that GIBH-LRA002, ethyl-2-amino-3-cyano-9-methyl-4-(trifluoromethyl)-4,9-dihydropyrano[2,3-b]indole-4-carboxylate, effectively reactivated the latent proviruses in a Jurkat-Lat cell line and primary CD4+ T cells from both chronic SIV-infected rhesus macaques and HIV-1 patients but without inducing systemic activation, making this compound attractive for potentially treating HIV-1 infection.YangQingQGuangzhou Institutes of Biomedicine and Health (GIBH) , Chinese Academy of Sciences , Guangzhou 510530 , China . Email: Sun_caijun@gibh.ac.cn.State Key Laboratory of Respiratory Disease , The First Affiliated Hospital of Guangzhou Medical University , Guangzhou , 510120 , China.DingYuyangYGuangzhou Institutes of Biomedicine and Health (GIBH) , Chinese Academy of Sciences , Guangzhou 510530 , China . Email: Sun_caijun@gibh.ac.cn.University of Chinese Academy of Sciences , Beijing , 100049 , China.FengFenglingFGuangzhou Institutes of Biomedicine and Health (GIBH) , Chinese Academy of Sciences , Guangzhou 510530 , China . Email: Sun_caijun@gibh.ac.cn.School of Life Sciences , University of Science and Technology of China (USTC) , Hefei , 230027 , China.PanEnxiangEGuangzhou Institutes of Biomedicine and Health (GIBH) , Chinese Academy of Sciences , Guangzhou 510530 , China . Email: Sun_caijun@gibh.ac.cn.University of Chinese Academy of Sciences , Beijing , 100049 , China.FanXiaozhenXGuangzhou Institutes of Biomedicine and Health (GIBH) , Chinese Academy of Sciences , Guangzhou 510530 , China . Email: Sun_caijun@gibh.ac.cn.School of Life Sciences , University of Science and Technology of China (USTC) , Hefei , 230027 , China.MaXiuchangXGuangzhou Institutes of Biomedicine and Health (GIBH) , Chinese Academy of Sciences , Guangzhou 510530 , China . Email: Sun_caijun@gibh.ac.cn.ChenLingLGuangzhou Institutes of Biomedicine and Health (GIBH) , Chinese Academy of Sciences , Guangzhou 510530 , China . Email: Sun_caijun@gibh.ac.cn.State Key Laboratory of Respiratory Disease , The First Affiliated Hospital of Guangzhou Medical University , Guangzhou , 510120 , China.ZhaoJunlingJInstitute of Medicinal Chemistry , School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou 510006 , P.R. China . Email: zhaojunl@iccas.ac.cn.SunCaijunC0000-0002-2000-7053Guangzhou Institutes of Biomedicine and Health (GIBH) , Chinese Academy of Sciences , Guangzhou 510530 , China . Email: Sun_caijun@gibh.ac.cn.engJournal Article20170725
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