A practical method of four-step synthesis towards novel ()-5-(methoxyimino)-3,5-dihydrobenzo[][1,2]oxazepin-4(1)-one antifungals is presented, where a commercially available pesticide and pharmacology intermediate, ()-methyl 2-(2-(bromomethyl)phenyl)-2-(methoxyimino)acetate (), was used as starting material. These compounds were confirmed by H NMR, C NMR, high-resolution mass spectroscopy and X-ray crystal structure. fungicidal evaluation, the moderate to high activities of several compounds against eight phytopathogenic fungi were demonstrated. Especially, the fungicidal activities of compounds and were comparable to those of the controls azoxystrobin and trifloxystrobin in precise virulence measurements for four fungi. These results suggested that dihydrobenzo[][1,2]oxazepin-4(1)-one analogues could be considered as potential fungicidal candidates for crop protection.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072479 | PMC |
| http://dx.doi.org/10.1039/c7md00025a | DOI Listing |
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