Herein, we disclose the development of a catalyst- and protecting-group-free microwave-enhanced Friedländer synthesis which permits the single-step, convergent assembly of diverse 8-hydroxyquinolines with greatly improved reaction yields over traditional oil bath heating (increased from 34% to 72%). This rapid synthesis permitted the discovery of novel biofilm-eradicating halogenated quinolines (MBECs = 1.0-23.5 μM) active against MRSA, MRSE, and VRE. These small molecules exhibit activity through mechanisms independent of membrane lysis, further demonstrating their potential as a clinically useful treatment option against persistent biofilm-associated infections.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072483 | PMC |
| http://dx.doi.org/10.1039/c6md00381h | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The detection of chloride in reinforced concrete, crucial for maintenance against damage from de-icing salt or seawater, is advanced by Laser-Induced Breakdown Spectroscopy (LIBS). This study demonstrates that integrating microwaves with LIBS enhances cement analysis, improving the signal-to-noise ratio by up to four times and extending the detection limit for chlorine to 0.17 ± 0.
View Article and Find Full Text PDFAmmonium Zincates as Catalysts for the Microwave-Enhanced Synthesis of Symmetric Piperazines by Regioselective Opening of Aziridines.
Chem Asian J
November 2024
Department of Chemistry, Università degli Studi di Milano and CNR-SCITEC, Via Golgi 19, 20133, Milano, Italy.
2,5-disubstituted N,N'-alkylpiperazines represent an interesting target in organic synthesis both for pharmaceutical or agrochemical applications and as a promising class of ligands in coordination chemistry. We report here a microwave-enhanced synthesis of these compounds starting from non-activated N-alkyl aziridines in the presence of catalytic amounts of simple ammonium metallates. A remarkable TOF of 2787.
View Article and Find Full Text PDFSynthesis of hydrochar from date palm seeds using microwave-enhanced hydrothermal carbonization and its application in dyes removal.
Int J Phytoremediation
November 2024
Water Management and Treatment Technologies Institute, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
This work reports new findings on the preparation of hydrochar from date palm () seeds through the application of the microwave hydrothermal carbonization (HTC) method. Optimization investigations involving temperatures and reaction times were conducted to establish the highest yield, achieving a maximum yield of 60.87%.
View Article and Find Full Text PDFWireless Powered Microwave-Light Conversion Platform with Dual-Stimulus Nanoresponder Coating for Deep-Seated Photodynamic Therapy.
ACS Nano
July 2024
School of Materials Science & Engineering, Peking University, Beijing 100871, China.
Traditional external field-assisted therapies, e.g., microwave (MW) therapy and phototherapy, cannot effectively and minimally damage eliminate deep-seated infection, owing to the poor penetrability of light and low reactive oxygen species (ROS) stimulation capability of MW.
View Article and Find Full Text PDFRapid, Point-of-Care Microwave Lysis and Electrochemical Detection of Directly from Stool Samples.
Bioengineering (Basel)
June 2024
School of Pharmacy & Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, UK.
The rapid detection of the spore form of has remained a challenge for clinicians. To address this, we have developed a novel, precise, microwave-enhanced approach for near-spontaneous release of DNA from spores via a bespoke microwave lysis platform. spores were microwave-irradiated for 5 s in a pulsed microwave electric field at 2.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!