ALK-fusion proteins play a fundamental role in the development of about 5% of non-small cell lung cancers. Herein, we identified the compound 5067-0952 as a potent ALK inhibitor, which inhibited cell growth, induced apoptosis, and suppressed the phosphorylation of ALK, subsequently blocking its downstream signaling pathway.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071718 | PMC |
| http://dx.doi.org/10.1039/c7md00305f | DOI Listing |
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