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Multidimensional characterization of craniofacial skeletal phenotype of obstructive sleep apnea in adults.
Eur J Orthod
December 2024
Professor, Department of Orthodontics, School of Dentistry, Kyung Hee University, Seoul 02453, Republic of Korea.
Objectives: We aimed to characterize a craniofacial skeletal phenotype (CSP) of adult obstructive sleep apnea (OSA) patients from a multidimensional perspective, exploring the impact of transverse skeletal discrepancy (TSD) on multivariable polysomnographic profiles.
Materials And Methods: This retrospective, cross-sectional study included 102 adult OSA patients. Sagittal, vertical, and transverse skeletal patterns were categorized on the cone beam computed tomography images.
Deep Learning and Hyperspectral Imaging for Liver Cancer Staging and Cirrhosis Differentiation.
J Biophotonics
January 2025
Nanjing University of Chinese Medicine, Nanjing, China.
Liver malignancies, particularly hepatocellular carcinoma (HCC), pose a formidable global health challenge. Conventional diagnostic techniques frequently fall short in precision, especially at advanced HCC stages. In response, we have developed a novel diagnostic strategy that integrates hyperspectral imaging with deep learning.
View Article and Find Full Text PDFPreclinical and First-In-Human Imaging of Novel [F]F-FAPI-FUSCC-07 Tracer: Comparative Prospective Study with [F]F-FAPI-42 and [F]F-FAPI-74.
Mol Pharm
January 2025
Department of Nuclear Medicine, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
This study aimed to develop and evaluate a novel fibroblast activation protein (FAP)-specific tracer, fluorine-18-labeled fibroblast activation protein inhibitor-FUSCC-07 ([F]F-FAPI-FUSCC-07), for use in both preclinical and clinical settings. Preclinical evaluations were conducted to assess the stability and partition coefficient of [F]F-FAPI-FUSCC-07. Experiments involving human glioma U87MG cells demonstrated its cellular uptake and inhibitory properties.
View Article and Find Full Text PDFDiagnostic approach for the rare anterior variant of mandibular bone depression often misdiagnosed as tumorous lesions.
J Dent Sci
January 2025
Department of Oral and Maxillofacial Radiology, Yonsei University College of Dentistry, Seoul, Republic of Korea.
Background/purpose: This study analyzed the clinical and imaging features of lingual mandibular bone depression (LMBD) in the anterior mandible, aiming to prevent misdiagnosis and unnecessary surgical procedures.
Materials And Methods: The patients who visited a university dental hospital for painless radiolucency in the anterior mandible from January 2010 to December 2022 were retrospectively reviewed. Twelve cases of LMBD in the anterior mandible that are confirmed by biopsy or long-term follow-up were identified.
High-precision and non-invasive measurement of crestal bone level by optical coherence tomography.
J Dent Sci
January 2025
School of Dentistry, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Background/purpose: Identifying crestal bone level (CBL) on the buccal and lingual aspects poses challenges in conventional dental radiographs. Given that optical coherence tomography (OCT) has the capability to non-invasively provide in-depth information about the periodontium, this in vitro study aimed to assess whether OCT can effectively identify periodontal landmarks and measure CBL in the presence of gingiva.
Materials And Methods: An in-house handheld scanning probe connected to a 1310-nm swept-source OCT (SS-OCT) system, along with self-developed algorithms were employed to measure the CBL in dental models with artificial gingiva.
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