Cancer-Specific Splicing Changes and the Potential for Splicing-Derived Neoantigens.

Cancer Cell

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, 408 E. 69th Street, New York, NY 10065, USA; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

Published: August 2018

In this issue of Cancer Cell, Kahles et al. perform a comprehensive analysis of RNA splicing across cancer types and identify novel correlations between genetic alterations and splicing in cancer. In addition, they identify that tumor-specific splicing has the potential to generate a large new class of tumor-specific neoantigens.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614861PMC
http://dx.doi.org/10.1016/j.ccell.2018.07.008DOI Listing

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