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Prospective Analysis of Confocal Laser Endomicroscopy for Assessment of the Resection Bed for Bladder Tumor.
Eur Urol Open Sci
January 2025
Department of Urology, Amsterdam UMC, Amsterdam, The Netherlands.
Background And Objective: Urothelial bladder cancer (UCB) care requires frequent follow-up cystoscopy and surgery. Confocal laser endomicroscopy (CLE), a probe-based optical technique for real-time microscopic evaluation, has shown promising accuracy for grading of UCB. We investigated the diagnostic accuracy of CLE-based assessment of the surgical radicality of the bladder resection bed (RB).
View Article and Find Full Text PDFLaryngeal Mucosal Tumor Mapping with Narrow Band Imaging and Confocal Laser Endomicroscopy.
Laryngoscope
November 2024
Department of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, U.S.A.
Confocal laser endomicroscopy (CLE) represents an emerging probe-based intraoperative optical imaging modality, contingent on differential fluoroscein uptake, equipped to improve intraoperative identification of subclinical mucosal disease. In the analysis herein, we describe improved sensitivity, compared to narrow band imaging and small-volume tissue biopsies, of CLE in the discrimination of occult disease based on cellular and subcellular morphology during endoscopic resection of early-staged larynx cancers. Laryngoscope, 2024.
View Article and Find Full Text PDFResolution of Acute Lung Allograft Rejection Detected by Probe-based Confocal Laser Endomicroscopy.
Am J Respir Crit Care Med
October 2024
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States;
The value of assessing deep disease healing by probe-based confocal laser endomicroscopy and histology for long-term prognosis of ulcerative colitis.
J Gastroenterol Hepatol
December 2024
Department of Gastroenterology, Peking University First Hospital, Beijing, China.
Article Synopsis
- The study aimed to evaluate long-term deep disease healing in ulcerative colitis (UC) patients by comparing different assessment methods like confocal laser endomicroscopy (CLE) and histological examination.
- Forty-two UC patients in remission underwent colonoscopy and were monitored for disease relapse, revealing that those showing signs of mucosal healing had significantly lower recurrence rates after 48 months compared to those without healing.
- The findings indicate that CLE and specific histological assessments, such as the ENHANCE index and Geboes scale, are effective predictors of long-term outcomes in UC patients, suggesting deeper healing correlates with lower recurrence rates.
The definitive diagnosis of patients with indeterminate biliary strictures remains challenging. Probe-based confocal laser endomicroscopy (pCLE) provides real-time histological assessment of bile duct tissues. Since no previous studies have evaluated the efficacy of pCLE under direct cholangioscopic visualization for biliary strictures that cannot be definitively diagnosed through endoscopic retrograde cholangiopancreatography using fluoroscopy, we prospectively assessed the feasibility and safety of this procedure in three cases.
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