AI Article Synopsis
- Label-free particle analysis is important in various industries and sciences but typically has lower throughput compared to fluorescence methods.* -
- This study introduces a new label-free analyzer that uses dual-comb coherent Raman scattering spectroscopy, achieving a high scan rate of 10 kHz.* -
- The analyzer successfully measured polystyrene microparticles at a rate of over 1000 particles per second, making it suitable for precise statistical analysis of numerous microparticles, including biological cells.*
Article Abstract
Label-free particle analysis is a powerful tool in chemical, pharmaceutical, and cosmetic industries as well as in basic sciences, but its throughput is significantly lower than that of fluorescence-based counterparts. Here we present a label-free single-particle analyzer based on broadband dual-comb coherent Raman scattering spectroscopy operating at a spectroscopic scan rate of 10 kHz. As a proof-of-concept demonstration, we perform broadband coherent anti-Stokes Raman scattering measurements of polystyrene microparticles flowing on an acoustofluidic chip at a high throughput of >1000 particles per second. This high-throughput label-free particle analyzer has the potential for high-precision statistical analysis of a large number of microparticles including biological cells.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1364/OL.43.004057 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!