AI Article Synopsis
- Amniotic band sequence is a congenital anomaly where maternal amniotic tissue creates bands around body parts, leading to limb and digit abnormalities in infants.
- The study reports a novel case involving three patients with complex craniofacial clefts and amniotic band sequence, including features like hypertelorism and facial clefts connected to hands.
- The findings suggest that complex facial clefts expose certain tissue areas in embryos, making them more likely to adhere to fetal hands, supporting existing theories on the causes of amniotic band syndrome.
Article Abstract
Amniotic band sequence is a complex congenital anomaly in which infants with typically no known genetic mutation have bands of maternal amniotic tissue wrapped around body parts, most commonly the limbs and digits. The authors report a novel variation on this presentation in 3 patients from 2 centers with complex craniofacial clefting and amniotic band sequence. They presented with hypertelorism, different forms of complex craniofacial clefting, and bands connecting ipsilateral hands to facial clefts, with digital-facial translocation in 2 cases. These findings support a model in which complex craniofacial clefts result in areas of exposed, sticky, and temporally and spatially coincident mesenchyme within the embryo that are susceptible to adherence of ipsilateral fetal hands. This strongly supports the intrinsic and adhesion theories of the etiology of amniotic band syndrome.
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| http://dx.doi.org/10.1097/SCS.0000000000004817 | DOI Listing |
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