Purpose: Photon counting arrays (PCAs), capable of measuring the spectral information of individual x-ray photons and recording that information digitally, provide a number of advantages compared to conventional, energy-integrating active matrix flat-panel imagers - such as reducing the undesirable effects of electronic readout noise and Swank noise. While contemporary PCAs are based on crystalline silicon, our group has been examining the use of polycrystalline silicon (poly-Si, a semiconductor material better-suited for the manufacture of large-area devices) for such arrays. In this study, a theoretical investigation of the front-end amplifiers of array pixels incorporating photon counting circuits is described - building upon circuit simulation techniques developed in a previous study. Results for amplifier circuit designs corresponding to prototype PCAs currently under development, as well as for hypothetical circuit designs identified in the study, are reported. In the simulations, performance metrics (such as signal gain, linearity of signal response, and energy resolution) as well as various measures of count rate are determined.

Methods: The simulations employed various input energy distributions (i.e., a 72 kVp spectrum as well as monoenergetic x rays) in order to determine circuit performance. To make the results representative of the properties of poly-Si, the simulations incorporated transistor characteristics that were empirically obtained from test devices. Optimal operating conditions for the circuits were determined by applying criteria to the performance metrics and identifying which conditions minimized settling time. Once the optimal operating conditions were identified, trains of input pulses simulating x-ray flux were used to determine two measures of count rate corresponding to dead time losses of 10% and 30% (referred to as CR and CR , respectively).

Results: The best-performing prototype amplifier design (implemented at a pixel pitch of 1 mm) exhibited CR and CR values (expressed in counts per second per pixel) of 8.4 and 21.6 kcps/pixel, respectively. A hypothetical amplifier design was derived by modifying transistor, resistor, and capacitor elements of the prototype amplifier designs. This hypothetical design (implemented at a pitch of 1 mm) exhibited CR and CR values of 154 and 381 kcps/pixel, respectively. When implemented at a pitch of 0.25 mm, the performance of that design increased to 210 and 491 kcps/pixel, respectively (corresponding to counts per second per unit area of 3.4 and 7.9 Mcps/mm ).

Conclusions: The simulation methodology described in this paper represents a useful tool for identifying promising designs for the amplifier component of photon counting arrays, as well as evaluating the analog signal and noise performance of those designs. The results obtained from the current study support the hypothesis that large-area, photon counting arrays based on poly-Si transistors can provide clinically useful count rates. Encouraged by these early results, further development of the methodology to assist in the identification and evaluation of even more promising designs, along with development and empirical characterization of prototype designs, is planned.

Download full-text PDF

Source
http://dx.doi.org/10.1002/mp.13128DOI Listing

Publication Analysis

Top Keywords

photon counting
20
counting arrays
16
count rate
12
theoretical investigation
8
arrays based
8
polycrystalline silicon
8
circuit designs
8
performance metrics
8
measures count
8
optimal operating
8

Similar Publications

Background: The latest generation of computed tomography (CT) systems based on photon-counting detector promises significant improvements in several clinical applications, including chest imaging.

Purpose: The aim of the study is to evaluate the image quality of ultra-high-resolution (UHR) photon-counting detector CT (PCD-CT) of the lung using four sharp reconstruction kernels.

Material And Methods: This retrospective study included 25 patients (11 women and 14 men; median age, 71 years) who underwent unenhanced chest CT from April to May 2023.

View Article and Find Full Text PDF

Defining the optimal radiation-induced lymphopenia metric to discern its survival impact in esophageal cancer.

Int J Radiat Oncol Biol Phys

January 2025

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston TX, United States of America; Department of Radiation Oncology, Amsterdam UMC, Amsterdam, The Netherlands.

Background: A detrimental association between radiation-induced lymphopenia (RIL) and oncologic outcomes in esophageal cancer patients has been established. However, an optimal metric for RIL remains undefined, but is important for application of this knowledge in clinical decision-making and trial designs. The aim of this study was to find the optimal RIL metric discerning survival.

View Article and Find Full Text PDF

Introduction: The use of urine cytobacteriological examination is a common and essential practice in medicine which helps guide therapeutic management in case of urinary tract infection. The cytological examination of urine samples can be done using the manual (microscopic) or automated technique. The automated approach, which involves the use of artificial intelligence, is faster, more reliable, and more efficient for laboratories.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigated the noise reduction capabilities of a photon-counting detector (PCD) in computed tomography (CT) using a model-based iterative reconstruction algorithm (QIR).
  • Forty repeated scans were conducted on a water phantom and compared with a conventional energy-integrating detector (EID) to assess noise characteristics.
  • Results showed that PCD-CT significantly reduced noise levels and improved image uniformity, demonstrating the effectiveness of QIR in decreasing noise without altering the overall distribution of noise values.
View Article and Find Full Text PDF

The rapid advancement of quantum key distribution technology in recent years has spurred significant innovation within the field. Nevertheless, a crucial yet frequently underexplored challenge involves the comprehensive evaluation of security quantum state modulation. To address this issue, we propose a novel framework for quantum group key distribution.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!