Dynamic Causal Modeling (DCM) has been extended for the analysis of electroencephalography (EEG) based on a specific biophysical and neurobiological generative model for EEG. Comparing to methods that summarize neural activities with linear relationships, the generative model enables DCM to better describe how signals are generated and better reveal the underlying mechanism of the activities occurring in human brains. Since DCM provides us with an approach to the effective connectivity between brain areas, with exponential ranking, the abnormality of the observed signals can be further located to a specific brain region. In this paper, a combination of DCM and exponential ranking is proposed as a new method aiming at searching for the abnormal brain regions which are associated with chronic tinnitus.
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http://dx.doi.org/10.1155/2018/8656975 | DOI Listing |
Alzheimers Dement (N Y)
January 2025
Indiana Alzheimer Disease Research Center and Center for Neuroimaging, Department of Radiology and Imaging Sciences Indiana University School of Medicine Indianapolis Indiana USA.
Introduction: The exponential growth of genomic datasets necessitates advanced analytical tools to effectively identify genetic loci from large-scale high throughput sequencing data. This study presents Deep-Block, a multi-stage deep learning framework that incorporates biological knowledge into its AI architecture to identify genetic regions as significantly associated with Alzheimer's disease (AD). The framework employs a three-stage approach: (1) genome segmentation based on linkage disequilibrium (LD) patterns, (2) selection of relevant LD blocks using sparse attention mechanisms, and (3) application of TabNet and Random Forest algorithms to quantify single nucleotide polymorphism (SNP) feature importance, thereby identifying genetic factors contributing to AD risk.
View Article and Find Full Text PDFEnviron Sci Process Impacts
December 2024
Anhui Bossco Environmental Protection Technology Co., Ltd, Ningguo, Anhui, 242301, China.
Contamination of heavy metals (HMs) has caused increasing concern due to their ecological toxicities and difficulties in degradation. The transport, retention, and release of HMs in porous media are highly related to their environmental fate and risk to groundwater. Column transport experiments and numerical simulations were conducted to investigate the retention and release behaviors of Cu, Pb, Cd, and Zn in the presence and absence of kaolin under varying ionic strengths and cation types.
View Article and Find Full Text PDFWater Sci Technol
December 2024
Laboratory of Membrane Separation Processes (LabProSeM), Department of Chemical Engineering, University of Santiago de Chile (USACH), Av. Libertador Bernardo O'Higgins 3363, Estación Central, Santiago 9170019, Chile E-mail:
The current global water crisis has prompted research into technologies that can reuse different water resources to mitigate water scarcity. The use of treated greywater can be proposed to provide additional water resources. By reusing this water in different applications, this water crisis can be mitigated at the local scale.
View Article and Find Full Text PDFMaterials (Basel)
November 2024
School of Civil and Resource Engineering, University of Science and Technology Beijing, Beijing 100083, China.
To achieve effective consolidation of fine particles in moraine and enhance the freeze-thaw resistance of the consolidated body, this study developed a novel grouting material using sodium silicate, lipid-based curing agents, and acidic catalysts. The gelation time and rheological properties of this material were tested. The freeze-thaw resistance was studied through changes in uniaxial compressive strength (UCS) after freeze-thaw cycles, while the consolidation mechanism was analyzed using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM).
View Article and Find Full Text PDFMol Ther Nucleic Acids
December 2024
Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA.
Aptamers are short single-stranded DNA or RNA molecules with high affinity and specificity for targets and are generated using the iterative systematic evolution of ligands by exponential enrichment (SELEX) process. Next-generation sequencing (NGS) revolutionized aptamer selections by allowing a more comprehensive analysis of SELEX-enriched aptamers as compared to Sanger sequencing. The current challenge with aptamer NGS datasets is identifying a diverse cohort of candidate aptamers with the highest likelihood of successful experimental validation.
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