This study presents the initial assessment for a new approach to frequency selectivity aimed at mimicking the function of the basilar membrane within the human cochlea. The term cochlea tonotopy refers to the passive frequency selectivity and a transformation from the acoustic wave into a frequency signal assisted by the hair cells in the organ of Corti. While high-frequency sound waves vibrate near the base of the cochlea (near the oval windows), low-frequency waves vibrate near the apex (at the maximum distance from the base), which suggests the existence of continuous frequency selectivity. Over the past few decades, frequency selectivity using artificial membranes has been utilized in acoustic transducers by mimicking cochlea tonotopy using cantilever-beam arrays with defined physical parameters such as length and thickness. Unlike the conventional cantilever-beam array type, the travelling wave propagation based-mechanoluminescence (ML) membrane made of ZnS:Cu- polydimethylsiloxane (ZnS:Cu-PDMS) composite that we describe here provides new frequency selectivity more similar to that demonstrated by the human membrane. Here, we explored the potential of the ML membrane to deliver new frequency selectivity by using a non-contact image sensor to measure visualized frequencies. We report that the ML basilar membrane can provide effective visualization of the distribution of strain rate associated with the position of maximal amplitude of the travelling wave.
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http://dx.doi.org/10.1038/s41598-018-30633-0 | DOI Listing |
Background: Traumatic anterior shoulder dislocation is the most common type of joint dislocation, with an incidence of 11 to 29 per 100 000 persons per year. Controversy still surrounds the recommendations for treatment and the available procedures for surgical stabilization.
Methods: This review is based on pertinent publications (2014-2024) that were retrieved by a selective search in the PubMed and Google Scholar databases.
JAMA Pediatr
January 2025
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Importance: Spontaneous reports have indicated that montelukast increases the risk of neuropsychiatric adverse events, and the US Food and Drug Administration added a boxed warning about these risks in 2020. However, the potential mechanism is not well understood, and the observational evidence is scarce, particularly in children.
Objective: To assess the potential association between the use of montelukast and the risk of neuropsychiatric adverse events in children and adolescents.
Support Care Cancer
January 2025
Department of Anesthesiology, School of Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama-Shi, 641-8509, Japan.
Purpose: Opioid-induced constipation (OIC) is problematic for patients with cancer receiving opioid therapy. Some guidelines recommend initiating regular laxatives at the same time as opioid analgesics. However, the effectiveness of prophylactic laxatives on OIC has not been widely demonstrated.
View Article and Find Full Text PDFJ Trauma Acute Care Surg
January 2025
From the Department of Surgery (T.G.) and Department of Biostatistics and Epidemiology (T.G.), University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; and Comparative Effectiveness and Clinical Outcomes Center (CECORC) (Z.L.B.), Riverside University Health Systems, Moreno Valley, CA.
Observational studies assessing causal effects of interventions are subject to indication (selection) bias, which may be difficult to eliminate using traditional multivariable techniques. When properly specified, propensity score-adjusted analysis may offer an advantage traditional regression by ensuring that investigators explicitly assess comparability of baseline prognostic factors between the treated and untreated. However, it is important to note that the effectiveness of a propensity score-adjusted analysis depends on the variables selected for the model and the analytic approach.
View Article and Find Full Text PDFJ Comp Eff Res
January 2025
ICON plc, Insights, Evidence & Value - Health Economics & Epidemiology, Langen, Germany.
To compare the efficacy and safety of lanadelumab versus other approved long-term prophylaxis (LTP) treatments in patients with pediatric hereditary angioedema (HAE) aged <12 years. A systematic literature review was conducted to identify studies of LTP in patients with HAE aged <12 years. Two studies met the inclusion criteria in an indirect treatment comparison of efficacy and safety data in pediatric HAE patients.
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