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The PEAT protein complexes are required for histone deacetylation and heterochromatin silencing. | LitMetric

AI Article Synopsis

  • In eukaryotes, regions of heterochromatin are often silenced through mechanisms like DNA methylation, but the specific processes involved in this silencing are not well understood.
  • A genetic screen led to the identification of a mutant, which demonstrated that the proteins EPCR1 and EPCR2 work together with various other proteins to form complexes (PEAT) that play a key role in maintaining heterochromatin silencing.
  • The PEAT complexes are responsible for several processes, including histone deacetylation and heterochromatin condensation, while also repressing small interfering RNA (siRNA) production and DNA methylation, highlighting the complex interactions that sustain heterochromatin silencing.

Article Abstract

In eukaryotes, heterochromatin regions are typically subjected to transcriptional silencing. DNA methylation has an important role in such silencing and has been studied extensively. However, little is known about how methylated heterochromatin regions are subjected to silencing. We conducted a genetic screen and identified an () mutant that releases heterochromatin silencing in We demonstrated that EPCR1 functions redundantly with its paralog EPCR2 and interacts with PWWP domain-containing proteins (PWWPs), AT-rich interaction domain-containing proteins (ARIDs), and telomere repeat binding proteins (TRBs), thus forming multiple functionally redundant protein complexes named PEAT (WWPs-PCRs-RIDs-RBs). The PEAT complexes mediate histone deacetylation and heterochromatin condensation and thereby facilitate heterochromatin silencing. In heterochromatin regions, the production of small interfering RNAs (siRNAs) and DNA methylation is repressed by the PEAT complexes. The study reveals how histone deacetylation, heterochromatin condensation, siRNA production, and DNA methylation interplay with each other and thereby maintain heterochromatin silencing.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166130PMC
http://dx.doi.org/10.15252/embj.201798770DOI Listing

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