AI Article Synopsis
- The study investigates the prevalence of birth defects (BDs) among different ethnic groups in Liuzhou City, Guangxi Province, China, highlighting the complex interplay of genetic, environmental, and cultural factors.
- Over a span of five years (2011-2015), data from 260,722 perinatal infants revealed an average BD prevalence of 25.24 per 1000, with Han ethnicity showing the highest rates compared to other groups such as Zhuang, Yao, Miao, and Dong.
- The findings suggest that the differences in BD risks among these ethnic groups may be influenced by genetic susceptibility, environmental conditions, and cultural practices, along with specific maternal factors like age and number of prenatal care visits
Article Abstract
Background: The causes of birth defects (BDs) are complex and include genetic and environmental factors and/or their interactions. More research is needed to describe the epidemiology of BDs within specific regions of China. This study focused on differences in the prevalence of BDs based on ethnicity in a large city in Guangxi Province, China.
Methods: Surveillance data of infants born in 114 registered hospitals in Liuzhou between 2011 and 2015 were analyzed to determine the epidemiology of BDs across five major ethnic groups. We calculated the prevalence of BDs and relative risk of BDs by ethnicity.
Results: There were 260,722 perinatal infants of which 6581 had BDs, with the average prevalence of 25.24 per 1000 perinatal infants (PIs). Prevalence data showed an obvious uptrend over the past 5 years. Han had the highest prevalence of total BDs (28.98‰), followed by Zhuang (25.19‰), Yao (18.50‰), Miao (15.78‰) and Dong (14.24‰). Relative to the Han; Zhuang, Miao, Yao, and Dong had a lower risk of musculoskeletal and urogenital malformations; Miao and Yao had a lower risk of cardiovascular malformation; and Dong had a lower risk of cardiovascular and craniofacial malformation. Several maternal risk factors were found to be associated with BDs (e.g., maternal and gestational age, number of antenatal care visits).
Conclusion: This study provided a comprehensive description of ethnic differences in the risk of BDs in Liuzhou City, China. Observed ethnic differences in the risk of BDs may be related to genetic susceptibilities, environment, cultural customs, or to potential combinations of these factors.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090596 | PMC |
| http://dx.doi.org/10.1186/s12889-018-5947-y | DOI Listing |
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