Acute syphilitic meningitis in an HIV-infected patient.

IDCases

Department of Medical Microbiology and Infection Prevention, VU medical center, Amsterdam, The Netherlands.

Published: July 2018

We present a case of acute syphilitic meningitis in a 28-year old HIV-infected patient, presenting with a seizure. MRI revealed a meningeal lesion with cortical involvement, and the patient described previous treatment for syphilis. Final diagnosis was established by PCR and spirochete staining on a brain biopsy, upon which the patient was successfully treated with benzylpenicillin.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077171PMC
http://dx.doi.org/10.1016/j.idcr.2018.e00423DOI Listing

Publication Analysis

Top Keywords

acute syphilitic
8
syphilitic meningitis
8
hiv-infected patient
8
meningitis hiv-infected
4
patient
4
patient case
4
case acute
4
meningitis 28-year
4
28-year hiv-infected
4
patient presenting
4

Similar Publications

A case of neuron-derived neurotrophic factor-positive, syphilis-related membranous nephropathy that achieved spontaneous remission.

CEN Case Rep

December 2024

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.

Neuron-derived neurotrophic factor (NDNF) was discovered as a target antigen in membranous nephropathy (MN) caused by syphilis. However, there have been few reports of NDNF-positive MN in Japan. A 19-year-old female patient was admitted to our hospital with nephrotic syndrome and acute kidney injury.

View Article and Find Full Text PDF
Article Synopsis
  • * Initial visual assessments revealed significant vision loss in the left eye and worsening conditions in the right eye, with diagnostic tests confirming syphilis as the underlying cause of the retinitis.
  • * After receiving treatment with benzathine penicillin and doxycycline, the patient's vision improved markedly in both eyes, demonstrating the effectiveness of addressing syphilitic retinitis.
View Article and Find Full Text PDF

Papilledema is a high-risk cause of vision changes in the Emergency Department (ED) and a critical physical examination finding because of its close association with etiologies that may progress to vision loss or death. Syphilis is a rare infectious cause of papilledema, with scarce case reports published showing its ability to develop such sequela. We present a case of a 35-year-old male with a past medical history of newly diagnosed HIV who originally presented to the ED with a rash and rapidly worsening visional changes.

View Article and Find Full Text PDF

Purpose: Syphilis is a re-emerging infectious disease with various systemic manifestations, including ocular involvement, which can lead to significant morbidity if untreated. This study aims to analyze the ocular manifestations of syphilis in patients treated at a Portuguese tertiary center over a 14-year period.

Patients And Methods: A retrospective review of patients diagnosed with syphilis who presented with ocular symptoms from 2010 to 2023 was conducted.

View Article and Find Full Text PDF

Persistent syphilitic ocular manifestations despite treatment: a case series.

J Ophthalmic Inflamm Infect

October 2024

Department of Ophthalmology, Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Article Synopsis
  • Penicillin is the primary treatment for syphilis, but some patients experience ongoing eye issues like visual loss due to chronic inflammation or incomplete treatment.
  • In a case series of three patients, two experienced persistent syphilitic retinal conditions despite being treated with penicillin, leading to additional treatments or reinforcement of therapy.
  • Recommendations emerging from these cases emphasize ensuring complete initial penicillin treatment and monitoring inflammatory responses to optimize recovery and visual outcomes.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!