Necrobiosis lipoidica: a rare complication of diabetes.

Drug repurposing offers a cost-effective strategy for developing therapies for rare diseases, which often face challenges in traditional drug development.
This study used a new drug identification and repurposing pipeline to discover molecular drivers and potential therapies for psoriasis, leading to the identification of both known and novel disease mechanisms.
The approach was further applied to necrobiosis lipoidica, revealing important disease drivers and potential treatments, demonstrating a high success rate in matching drugs to identified molecular targets.

Dtsch Arztebl Int

November 2024

Leg ulcers, primarily located below the knee, can stem from various causes with around 80% resulting from chronic venous insufficiency (CVI) or peripheral arterial occlusive disease (PAOD), necessitating diverse medical specialists for treatment.
The diagnostic approach follows the ABCDE rule, which includes personalized history-taking, bacteriological testing, clinical exams, and additional tests to accurately identify the cause of the ulcer, such as vascular issues or other diseases.
Effective treatment relies on prompt differential diagnosis, highlighting the need for collaboration among different medical specialties due to the complexity of leg ulcers and the challenges posed by limited high-quality research.

J Allergy Clin Immunol

November 2024

Department of Dermatology, Yale School of Medicine, New Haven, Conn; Department of Pathology, Yale School of Medicine, New Haven, Conn. Electronic address:

Noninfectious cutaneous granulomatous disorders like cutaneous sarcoidosis, granuloma annulare, necrobiosis lipoidica, and necrobiotic xanthogranuloma exhibit distinct immune responses and histological features due to variations in macrophage inflammation.
The study used spatial transcriptomics to analyze the immune activation patterns in these disorders, revealing that each condition has unique characteristics, such as polarized type 1 responses in cutaneous sarcoidosis and mixed type 1 and type 2 responses in granuloma annulare.
Findings suggest that different immune activation patterns are associated with specific histological changes, highlighting the complexity and individuality of these inflammatory skin conditions.

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