-Methyl carbamoylimidazole is a safe and practical alternative to methyl isocyanate for carbamoylation reactions. We have developed a new chemical route for its synthesis from methyl iodide and applied this to the synthesis of -[C]methyl carbamoylimidazole as a new [C]synthon to radiolabel biomolecules for PET imaging research. -[C]methyl carbamoylimidazole was prepared from [C]methyl iodide in 70-74% radiochemical yield (decay corrected) and can be used in situ for further reaction without purification. The reactivity of -[C]methyl carbamoylimidazole was demonstrated in a series of [C]carbamoylation reactions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061098 | PMC |
| http://dx.doi.org/10.1007/s10967-018-5948-4 | DOI Listing |
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Radiosynthesis and reactivity of -[C]methyl carbamoylimidazole.
J Radioanal Nucl Chem
June 2018
4Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Box 65, Addenbrooke's Hospital, Cambridge, CB2 0QQ UK.
-Methyl carbamoylimidazole is a safe and practical alternative to methyl isocyanate for carbamoylation reactions. We have developed a new chemical route for its synthesis from methyl iodide and applied this to the synthesis of -[C]methyl carbamoylimidazole as a new [C]synthon to radiolabel biomolecules for PET imaging research. -[C]methyl carbamoylimidazole was prepared from [C]methyl iodide in 70-74% radiochemical yield (decay corrected) and can be used in situ for further reaction without purification.
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