AI Article Synopsis
- Researchers synthesized new hydrazide derivatives from N-substituted amidrazones and cyclic anhydrides, targeting anti-inflammatory and antibacterial properties.
- The compounds were analyzed using advanced H-C NMR techniques, revealing two forms in solution and one confirmed structure via X-ray diffraction.
- Among the compounds, three showed anti-inflammatory effects on blood cells similar to ibuprofen, with one significantly reducing lymphocyte growth while demonstrating low toxicity, though antibacterial effects were generally weak, especially for Gram-positive strains.
Article Abstract
Abstract: The series of new hydrazide derivatives were synthesized in reactions of N-substituted amidrazones with cyclic anhydrides as potential anti-inflammatory and antibacterial agents. The compounds were characterized by H-C two-dimensional NMR techniques, which revealed the presence of two tautomeric forms in DMSO- solutions, while the molecular structure of one species was confirmed by single-crystal X-ray diffraction. The anti-inflammatory effects of hydrazides on peripheral blood mononuclear cells were experimentally evaluated. Three compounds showed antiproliferative activity comparable to ibuprofen. One derivative demonstrated strong reduction of lymphocyte proliferation stimulated by anti-CD3 antibody (by 90%) and PHA, as well as low cell toxicity. The obtained compounds exhibited relatively weak antibacterial activity; they were more effective against Gram-positive bacterial strains.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060958 | PMC |
| http://dx.doi.org/10.1007/s00706-018-2197-8 | DOI Listing |
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