PF4 (platelet factor 4) is the first host defense peptide identified from platelets that kills malaria parasites. In a recent study, a cyclic PF4 derivative, cPF4PD, is developed, which inherits the antiparasitic effect of PF4 but excludes its potential side effects. cPF4PD is a promising novel antimalarial agent of human origin.
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| http://dx.doi.org/10.1016/j.pt.2018.07.013 | DOI Listing |
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