AI Article Synopsis
- Multiple Myeloma (MM) is an incurable cancer linked to the abnormal growth of plasma cells, with the Interferon Regulatory Factor 4 (IRF4) playing a crucial role in its development.
- IRF4 is essential for B cell differentiation and immunoglobulin production, and its overexpression in MM is often caused by genetic mutations, contributing to the survival of cancer cells.
- The text reviews IRF4's functions in normal and malignant B cells, evaluates how MM disrupts IRF4 activity, and explores current treatments along with the potential for directly targeting IRF4 in therapy.
Article Abstract
Multiple Myeloma (MM) is an incurable hematologic malignancy characterized by abnormal proliferation of plasma cells. Interferon Regulatory Factor 4 (IRF4), a member of the interferon regulatory family of transcription factors, is central to the genesis of MM. IRF4 is highly expressed in B cells and plasma cells where it plays essential roles in controlling B cell to plasma cell differentiation and immunoglobulin class switching. Overexpression of IRF4 is found in MM patients' derived cells, often as a result of activating mutations or translocations, where it is required for their survival. In this review, we first describe the roles of IRF4 in B cells and plasma cells and then analyse the subversion of the IRF4 transcriptional network in MM. Moreover, we discuss current therapies for MM as well as direct targeting of IRF4 as a potential new therapeutic strategy.
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| http://dx.doi.org/10.1016/j.leukres.2018.07.025 | DOI Listing |
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