AI Article Synopsis
- SUMOylation modifies proteins, affecting their stability, location, and interactions, which can influence critical processes like Epithelial-Mesenchymal Transition (EMT).
- The secreted protein TGFβ is a major player in inducing EMT, significant for both normal development and cancer progression.
- The connection between TGFβ-induced EMT and the SUMO system offers insights into cancer behavior and potential new treatment strategies.
Article Abstract
Protein post-translational modification by the small ubiquitin-like modifier (SUMO), or SUMOylation, can regulate the stability, subcellular localization or interactome of a protein substrate with key consequences for cellular processes including the Epithelial-Mesenchymal Transition (EMT). The secreted protein Transforming Growth Factor beta (TGFβ) is a potent inducer of EMT in development and homeostasis. Importantly, the ability of TGFβ to induce EMT has been implicated in promoting cancer invasion and metastasis, resistance to chemo/radio therapy, and maintenance of cancer stem cells. Interestingly, TGFβ-induced EMT and the SUMO system intersect with important implications for cancer formation and progression, and novel therapeutics identification.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115711 | PMC |
| http://dx.doi.org/10.3390/cancers10080264 | DOI Listing |
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