Meta-Analysis Reveals the Association Between Male Occupational Exposure to Solvents and Impairment of Semen Parameters.

J Occup Environ Med

Laboratoire de Biologie de la Reproduction-CECOS, AP-HM La Conception, Pole Parents Enfants, Marseille, France (Drs Ianos, Perrin); AP-HM, La Timone, Service de Médecine et Santé au Travail, Marseille, France (Drs Ianos, Sari-Minodier, Lehucher-Michel); Aix Marseille Univ, Univ Avignon, CNRS, IRD, IMBE, Marseille, France (Drs Sari-Minodier, Perrin); Santé Publique et Maladies Chroniques (SPMC EA 3279), Faculté de Médecine, Aix Marseille Université, Marseille, France (Drs Villes, Lehucher-Michel, Loundou).

Published: October 2018

Objectives: Solvent exposure is among the most common occupational exposures to chemical toxicants; data about the impact of such exposure on semen parameters are contradictory. We conducted the first meta-analysis to evaluate the risk of alteration in semen parameters related to occupational exposure to solvents.

Methods: From the PubMed database, we selected studies analyzing the semen of subjects occupationally exposed to solvents, compared with unexposed controls. The meta-analysis was performed on the various semen parameters analyzed in both populations.

Results: Seven studies were included in the study. The meta-analysis revealed a significant decrease in ejaculate volume [standardized mean difference (SMD) = -0.35 (-0.63 to -0.07)] and sperm concentration [SMD = -0.36 (-0.64 to -0.08)] in workers exposed to solvents compared with unexposed controls.

Conclusion: Our results highlight the importance of preventing reprotoxic risks to male fertility in the workplace.

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http://dx.doi.org/10.1097/JOM.0000000000001422DOI Listing

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