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| http://dx.doi.org/10.1113/JP276950 | DOI Listing |
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Does the modified shuttle test exhibit a ceiling effect in healthy and cystic fibrosis children and adolescents?
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Department of Physiotherapy, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya (UIC), Barcelona - Spain.
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View Article and Find Full Text PDF[Long-term courses of anxiety disorders].
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Klinik für Psychiatrie und Psychotherapie, CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Deutschland.
Background: At present there is no comprehensive overview of the long-term development of the clinical picture, disease-associated impairments and neurobiological correlates of anxiety disorders as well as what influence certain risk factors and treatment have on the prognosis.
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State-dependent inter-network functional connectivity development in neonatal brain from the developing human connectome project.
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Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China. Electronic address:
Although recent studies have consistently reported the emergence of resting-state networks in early infancy, the changes in inter-network functional connectivity with age are controversial and the alterations in its dynamics remain unclear at this stage. This study aimed to investigate dynamic functional network connectivity (dFNC) using resting-state functional MRI in 244 full-term (age: 37-44 weeks) and 36 preterm infants (age: 37-43 weeks) from the dHCP dataset. We evaluated whether early dFNC exhibits age-dependent changes and is influenced by preterm birth.
View Article and Find Full Text PDFBoosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice.
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Deciphering the complex interplay between neuronal activity and mitochondrial function is pivotal in understanding brain aging, a multifaceted process marked by declines in synaptic function and mitochondrial performance. Here, we identified an age-dependent coupling between neuronal and synaptic excitation and mitochondrial DNA transcription (E-TC), which operates differently compared to classic excitation-transcription coupling in the nucleus (E-TC). We demonstrated that E-TC repurposes molecules traditionally associated with E-TC to regulate mitochondrial DNA expression in areas closely linked to synaptic activation.
View Article and Find Full Text PDFChallenges in magnetic resonance imaging-based detection of clinically significant prostate cancer in young patients: two alternative approaches.
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Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Background: Addition of magnetic resonance imaging (MRI) in prostate cancer screening remains controversial issue. Despite the increased utilization of MRI, several studies have revealed its potential suboptimal diagnostic efficacy in young patients. This study aimed to further substantiate the limited diagnostic efficiency of MRI positivity [defined as Prostate Imaging Reporting and Data System (PI-RADS) scores ≥3] among young individuals aged ≤55 years suspected of prostate cancer, and more significantly, to evaluate two proposed approaches.
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