Precise size control of layered double hydroxide nanoparticles (LDHNPs) is crucial for their applications in anion exchange, catalysis, and drug delivery systems. Here, we report the synthesis of LDHNPs through a reconstruction method, using tripodal ligands (e.g., tris(hydroxymethyl)aminomethane; THAM). We found that the mechanism of reconstruction at least includes a dissolution-recrystallization process rather than topotactic transformation. THAM is immobilized on the surface of recrystallized LDHNPs with tridentate linkages, suppressing their crystal growth especially in lateral directions. The particle size of the LDHNPs is precisely controlled by the concentration of THAM regardless of the synthetic routes, such as coprecipitation and reconstruction. It is suggested that the particle size is controlled on the basis of Ostwald ripening which is governed by the equilibrium of the surface modification reaction.
State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, 30 Puzhu Road, Nanjing, 211816, P. R. China.
Crystalline membranes, represented by the metal-organic framework (MOF) with well-defined angstrom-sized apertures, have shown great potential for molecular separation. Nevertheless, it remains a challenge to separate small molecules with very similar molecular size differences due to angstrom-scale defects during membrane formation. Herein, a stepwise assembling strategy is reported for constructing MOF membranes with intrinsic angstrom-sized lattice aperture lattice to separate organic azeotropic mixtures separation.
Study Question: To what extent are self-reported diagnoses of food allergies associated with fecundability, the per-cycle probability of conception?
Summary Answer: Fecundability was not appreciably associated with self-reported food allergy diagnoses, number of food allergies, age at first diagnosis, or time since last allergic reaction.
What Is Known Already: Food allergies are atopic diseases that are characterized by an inappropriate immune response to a normally harmless dietary substance. While some studies have observed associations between atopic disorders and infertility, no study has examined the association between food allergies and fecundability, the per-cycle probability of conception.
Cancer is a deadly disease with complex pathophysiological nature and is the leading cause of death worldwide. Traditional diagnosis methods often detect cancer at a considerably critical stage and the conventional methods of treatment like chemotherapy, radiation therapy, targeted therapy, and immunotherapy have several limitations, multidrug resistance, cytotoxicity, and lack of specificity are a few examples. These pose substantial challenge for effective and favourable cancer treatment.
Gold nanoparticles (AuNPs) have emerged as promising candidates for cancer therapy due to their unique physicochemical properties and biocompatibility. In this study, we investigate the synthesis, characterization, and therapeutic potential of AuNPs in breast cancer treatment. Further, it establishes a comprehensive understanding of the mechanisms by which AuNPs suppress angiogenesis and breast cancer growth, identifying novel targets and signaling nodes contributing to the anti-tumor effects of AuNPs.
Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.
