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Model-Based Approach for Optimizing Ceftobiprole Dosage in Pediatric Patients.
Antimicrob Agents Chemother
October 2021
Basilea Pharmaceutica International Ltd., Basel, Switzerland.
Ceftobiprole is an advanced-generation cephalosporin for intravenous administration with activity against Gram-positive and Gram-negative organisms. A population pharmacokinetic (PK) model characterizing the disposition of ceftobiprole in plasma using data from patients in three pediatric studies was developed. Model-based simulations were subsequently performed to assist in dose optimization for the treatment of pediatric patients with hospital-acquired or community-acquired pneumonia.
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Eur J Clin Pharmacol
December 2018
Institute of Clinical Pharmacology, Santa Maria della Misericordia University Hospital of Udine, Azienda Sanitaria Universitaria Integrata di Udine, P. le S. Maria della Misericordia 3, 33100, Udine, Italy.
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